Photoperiod Induces DNA Methylation Changes in the Melatonin Receptor 1A Gene in Ewes
Animals, 2023 Research has shown that MTNR1A plays an essential role in the estrus cycle and seasonal reproduction changes in sheep. However, few people have focused on the DNA methylation of MTNR1A by season or photoperiod.
Xiaoyun He +3 more
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Targets for the MalI repressor at the divergent Escherichia coliK-12malX-malI promoters [PDF]
, 2010 Random mutagenesis has been used to identify the target DNA sites for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. The malX promoter is repressed by MalI binding to a DNA site located from position -24 to position -9 ...
Barnard +22 more
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Veterinary Sciences, 2020 DNA methylation of different gene components, including different exons and introns, or different lengths of exons and introns is associated with differences in gene expression.
Xiao Wang, Haja N. Kadarmideen
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CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]
, 2018 The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad +7 more
core +1 more source
A nucleosome-free dG-dC-rich sequence element promotes constitutive transcription of the essential yeast RIO1 gene [PDF]
, 2003 RIO1 is an essential gene that encodes a protein serine kinase and is transcribed constitutively at a very low level. Transcriptional activation of RIO1 dispenses with a canonical TATA box as well as with classical transactivators or specific DNAbinding ...
Angermayr, M. +2 more
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Promoting human promoters [PDF]
Molecular Systems Biology, 2006 Mol Syst Biol. 2: 2006.0030 The effect of transcription factors on human gene expression can now be quantified owing to a new computational approach. The method was successfully applied to the cases of the cell cycle program, and for liver‐specific gene expression. Transcriptional regulation of gene expression plays a major role in the acquisition of
Furman, Itay, Pilpel, Yitzhak
openaire +1 more source
Predicting bacterial promoter function and evolution from random sequences
eLife, 2022 Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we developed
Mato Lagator +6 more
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CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]
, 2019 The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad +8 more
core +1 more source
ABCA1 gene promoter methylation and sudden cardiac death
Бюллетень сибирской медицины, 2021 Aim. A study of the association of the methylation of the promoter of the ABCA1 gene with sudden cardiac death(SCD).Materials and methods. The study design is based on the case-control principle.
A. A. Ivanova +8 more
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Structural visualization of key steps in human transcription initiation. [PDF]
, 2013 Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie +3 more
core +1 more source