Results 21 to 30 of about 1,392,700 (321)
Proceedings of the National Academy of Sciences of the United States of America, 1985 The RNA polymerase gene of bacteriophage T7 has been cloned into the plasmid pBR322 under the inducible control of the lambda PL promoter. After induction, T7 RNA polymerase constitutes 20% of the soluble protein of Escherichia coli, a 200-fold increase ...
S. Tabor, C. Richardson
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Predicting bacterial promoter function and evolution from random sequences
eLife, 2022 Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we developed
Mato Lagator +6 more
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Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
New England Journal of Medicine, 2015 BACKGROUND The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five glioma molecular groups with the use of three alterations ...
J. Eckel-Passow +35 more
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Frontiers in Bioengineering and Biotechnology, 2022 Lignin is essential for plant growth, structural integrity, biotic/abiotic stress resistance, and water transport. Besides, lignin constitutes 10–30% of lignocellulosic biomass and is difficult to utilize for biofuel production. Over the past few decades,
Yongli Wang +7 more
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Relationship between promoter sequence and its strength in gene expression [PDF]
Eur. Phys. J. E 37 (2014) 86, 2014 In this study, through various tests one theoretical model is presented to describe the relationship between promoter strength and its nucleotide sequence. Our analysis shows that, promoter strength is greatly influenced by nucleotide groups with three adjacent nucleotides in its sequence.
arxiv +1 more source
MatInspector and beyond: promoter analysis based on transcription factor binding sites
Bioinform., 2005 MOTIVATION Promoter analysis is an essential step on the way to identify regulatory networks. A prerequisite for successful promoter analysis is the prediction of potential transcription factor binding sites (TFBS) with reasonable accuracy.
Cartharius K +9 more
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Methylation status of hypothalamic Mkrn3 promoter across puberty
Frontiers in Endocrinology, 2023 Makorin RING finger protein 3 (MKRN3) is an important factor located on chromosome 15 in the imprinting region associated with Prader-Willi syndrome. Imprinted MKRN3 is expressed in hypothalamic regions essential for the onset of puberty and mutations in
Pavlos Fanis +11 more
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TFEB Gene Promoter Variants Effect on Gene Expression in Acute Myocardial Infarction
Frontiers in Cell and Developmental Biology, 2021 Autophagy is involved in many physiological processes. Transcription factor EB (TFEB) is a master regulator of autophagy and coordinates the expression of autophagic proteins, lysosomal hydrolases, and lysosomal membrane proteins.
Jie Zhang +9 more
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Synthetic promoter design in Escherichia coli based on a deep generative network
Nucleic Acids Research, 2020 Promoter design remains one of the most important considerations in metabolic engineering and synthetic biology applications. Theoretically, there are 450 possible sequences for a 50-nt promoter, of which naturally occurring promoters make up only a ...
Ye Wang +5 more
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MhYTP1 and MhYTP2 from Apple Confer Tolerance to Multiple Abiotic Stresses in Arabidopsis thaliana
Frontiers in Plant Science, 2017 The first YTH domain-containing RNA binding protein (YTP) was found in rat, where it was related to oxidative stress. Unlike characterizations in yeast and animals, functions of plant YTPs are less clear. Malus hupehensis (Pamp.) Rehd.
Na Wang +8 more
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