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<i>Cis</i>-regulatory elements operating in the trophoblast. [PDF]
Front Cell Dev BiolThe placenta is vital for supporting embryonic development and ensuring a successful pregnancy. Its diverse functions are carried out by specialized trophoblast cell types, including the progenitor cytotrophoblast, the multinucleated syncytiotrophoblast, and the invasive extravillous trophoblast.
Vcelkova T, Latos PA.
europepmc +3 more sources
Identifying regulatory elements in eukaryotic genomes [PDF]
Briefings in Functional Genomics & Proteomics, 2009 Proper development and functioning of an organism depends on precise spatial and temporal expression of all its genes. These coordinated expression-patterns are maintained primarily through the process of transcriptional regulation. Transcriptional regulation is mediated by proteins binding to regulatory elements on the DNA in a combinatorial manner ...
Leelavati Narlikar, Ivan Ovcharenko
exaly +3 more sources
Uncovering Drug-Responsive Regulatory Elements
Pharmacogenomics, 2015 Nucleotide changes in gene regulatory elements can have a major effect on interindividual differences in drug response. For example, by reviewing all published pharmacogenomic genome-wide association studies, we show here that 96.4% of the associated single nucleotide polymorphisms reside in noncoding regions. We discuss how sequencing technologies are
Marcelo R Luizon, Nadav Ahituv
exaly +6 more sources
Regulatory Elements for Gene Therapy of Epilepsy. [PDF]
CellsThe problem of drug resistance in epilepsy means that in many cases, a surgical treatment may be advised. But this is only possible if there is an epileptic focus, and resective brain surgery may have adverse side effects. One of the promising alternatives is gene therapy, which allows the targeted expression of therapeutic genes in different brain ...
Chesnokova E +3 more
europepmc +4 more sources
Regulatory transposable elements in the encyclopedia of DNA elements
Nature Communications, 2023 Abstract Transposable elements (TEs) make up about half of the human genome and many have the biochemical hallmarks of tissue- or cell type-specific cis -regulatory elements. While some TEs have been rigorously documented to contribute directly to host gene regulation, we still have
Alan Y. Du +4 more
openaire +4 more sources
Function and Regulation of Nuclear DNA Sensors During Viral Infection and Tumorigenesis
Frontiers in Immunology, 2021 IFI16, hnRNPA2B1, and nuclear cGAS are nuclear-located DNA sensors that play important roles in initiating host antiviral immunity and modulating tumorigenesis.
Fan Zhang +6 more
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Investigation of regulatory elements related to superoxide dismutase enzyme genes in wheat [PDF]
بیوتکنولوژی و بیوشیمی غلات, 2023 Introduction: Wheat, like other plants, uses antioxidant enzymes to deal with the high production of free oxygen radicals. Antioxidant enzymes are proteins or polypeptides that are activated in cooperation with cellular substances or mineral elements and
Armin Saed-Moucheshi, Hooshmand Safari
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Cis-Regulatory Elements in Mammals
International Journal of Molecular Sciences, 2023 In cis-regulatory elements, enhancers and promoters with complex molecular interactions are used to coordinate gene transcription through physical proximity and chemical modifications. These processes subsequently influence the phenotypic characteristics of an organism.
Xingyu Liu +8 more
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Identification of Genes and inducible regulatory elements in response to heat and cold stresses in barley (Hordeum vulgare L.) [PDF]
بیوتکنولوژی و بیوشیمی غلات, 2022 Introduction: Barley (Hordeum vulgare), a member of the Poaceae family, is an important cereal grown in temperate climates worldwide. It was one of the first cultivated grains, especially in Eurasia 10,000 years ago. Globally, 70% of barley production is
Danial Kahrizi
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Parallel genetics of regulatory sequences using scalable genome editing in vivo
Cell Reports, 2021 Summary: How regulatory sequences control gene expression is fundamental for explaining phenotypes in health and disease. Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts ...
Jonathan J. Froehlich +6 more
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