Results 1 to 10 of about 302,293 (261)
Viruses, 2023 G-quadruplexes (G4s) are unique non-canonical four-stranded nucleic acid secondary structures formed by guanine-rich DNA or RNA sequences. Sequences with the potential to form quadruplex motifs (pG4s) are prevalent throughout the genomes of all organisms,
Rajiv Pathak
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Regulatory pattern Identification in nucleic acid sequences [PDF]
Nucleic Acids Research, 1983 In addition to the sequence homologies and statistical patterns identified among numerous genetic sequences, there are subtler classes of patterns for which most current computer search methods offer very limited utility. This class includes various presumptive eukaryotic regulatory sites.
J R, Sadler, M S, Waterman, T F, Smith
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Computer analysis of nucleic acid regulatory sequences. [PDF]
Proceedings of the National Academy of Sciences, 1977 We describe a computer program designed to facilitate the analysis of nucleic acid sequences. The program can search several nucleic acid sequences for oligonucleotides common to all of them. It can examine a DNA or RNA sequence for two kinds of homologous regions--repetitions and dyad symmetries.
L J, Korn, C L, Queen, M N, Wegman
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Crosstalk between G-quadruplex and ROS
Cell Death and Disease, 2023 The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid base damage, DNA strand breakage, inter- and intra-strand cross-linking of nucleic acids, and protein-DNA cross-linking involved in the pathogenesis of cancer ...
Songjiang Wu +8 more
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A combined immunoprecipitation, mass spectrometric and nucleic acid sequencing approach to determine microRNA-mediated post-transcriptional gene regulatory networks [PDF]
Briefings in Functional Genomics, 2010 While initiation of transcription has attracted the most attention in the field of gene regulation, it has become clear that additional stages in the gene expression cascade including post-transcriptional events are under equally exquisite control.
Jeffrey N, Savas, Naoko, Tanese
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Identification and characterization of the Hfq bacterial amyloid region DNA interactions
BBA Advances, 2021 Nucleic acid amyloid proteins interactions have been observed in the past few years. These interactions often promote protein aggregation. Nevertheless, molecular basis and physiological consequences of these interactions are still poorly understood ...
Florian Turbant +6 more
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Cis-regulatory hairpin-shaped mRNA encoding a reporter protein: catalytic sensing of nucleic acid sequence at single nucleotide resolution [PDF]
Nature Protocols, 2007 DNA sensing at a single nucleotide resolution is achieved using a hairpin-shaped, unmodified (unlabeled) RNA probe or the precursor double-stranded DNA (dsDNA) in a prokaryotic cell-free translation medium. The molecular-beacon-like probe consists of a loop region that is complementary to the target sequence and a stem composed of a ribosome-binding ...
Narita, Atsushi +3 more
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Bio-Protocol, 2021 R-loops are non-canonical nucleic structures composed of an RNA–DNA hybrid and a displaced ssDNA. Originally identified as a source of genomic instability, R-loops have been shown over the last decade to be involved in the targeting of proteins and to be
Célia Alecki, Nicole Francis
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Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. [PDF]
Proceedings of the National Academy of Sciences, 1987 We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor. The nucleotide sequence of the thrombomodulin cDNA allows us to provide a complete picture of the structure of this endothelial cell receptor, and to ...
R W, Jackman +4 more
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Inference of splicing regulatory activities by sequence neighborhood analysis. [PDF]
PLoS Genetics, 2006 Sequence-specific recognition of nucleic-acid motifs is critical to many cellular processes. We have developed a new and general method called Neighborhood Inference (NI) that predicts sequences with activity in regulating a biochemical process based on ...
Michael B Stadler +5 more
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