Scientific Reports, 2022 Nucleic acid motifs consist of conserved and variable nucleotide regions. For functional action, several motifs are combined to modules. The tool AIModules allows identification of such motifs including combinations of them and conservation in several ...
Muharrem Aydinli +2 more
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Molecular Evolution and Functional Diversification of Replication Protein A1 in Plants [PDF]
, 2016 Replication protein A (RPA) is a heterotrimeric, single-stranded DNA binding complex required for eukaryotic DNA replication, repair, and recombination. RPA is composed of three subunits, RPA1, RPA2, and RPA3.
Aklilu, Behailu B., Culligan, Kevin M.
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Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
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Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacI-galR family of regulatory genes [PDF]
, 1997 malR of Strepomyces coelicolor A3(2) encodes a homologue of the Lacl/Galr family of repressor proteins, and is divergently transcribed from the malEFG gene cluster, which encodes components of an ATP-dependent transport system that is required for ...
Bibb, M.J. +4 more
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NucBase, an easy to use read mapper for small RNAs
Mobile DNA, 2013 Background High-throughput deep-sequencing technology has generated an unprecedented number of expressed sequence reads that offer the opportunity to get insight into biological systems.
Dufourt Jeremy +4 more
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Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq [PDF]
, 2016 © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities.
Chang, Yiming K +8 more
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Regulatory motif discovery using a population clustering evolutionary algorithm [PDF]
, 2007 This paper describes a novel evolutionary algorithm for regulatory motif discovery in DNA promoter sequences. The algorithm uses data clustering to logically distribute the evolving population across the search space. Mating then takes place within local
Lones, Michael A., Tyrrell, Andy M.
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Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
Frasson, Ilaria +8 more
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Long-range genomic enrichment, sequencing, and assembly to determine unknown sequences flanking a known microRNA. [PDF]
PLoS ONE, 2013 Conserved plant microRNAs (miRNAs) modulate important biological processes but little is known about conserved cis-regulatory elements (CREs) surrounding MIRNA genes.
Zhaorong Ma, Michael J Axtell
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Molecules, 2021 G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important
Loukiani Savva, Savvas N. Georgiades
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