Results 21 to 30 of about 1,489,667 (310)
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
Microbiology Spectrum, 2022 Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and the poor ...
Alexander Kühbacher +7 more
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Multigenome DNA sequence conservation identifies Hox cis-regulatory elements [PDF]
, 2008 To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how
De Buysscher, Tristan +7 more
core +3 more sources
Mechanisms of robustness in gene regulatory networks involved in neural development
Frontiers in Molecular Neuroscience, 2023 The functions of living organisms are affected by different kinds of perturbation, both internal and external, which in many cases have functional effects and phenotypic impact.
Camila D. Arcuschin +4 more
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A unified architecture of transcriptional regulatory elements [PDF]
Trends in Genetics, 2015 Abstract Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad
Andersson, Robin +2 more
openaire +3 more sources
Functional Enrichment Analysis of Regulatory Elements [PDF]
Biomedicines, 2022 Statistical methods for enrichment analysis are important tools to extract biological information from omics experiments. Although these methods have been widely used for the analysis of gene and protein lists, the development of high-throughput technologies for regulatory elements demands dedicated statistical and bioinformatics tools.
Adrian Garcia-Moreno +7 more
openaire +5 more sources
eLife, 2016 In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in
Jordi Solana +11 more
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Frontiers in Cell and Developmental Biology, 2020 Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase domain-like protein).
Kaijiang Xia +42 more
doaj +1 more source
Latent regulatory potential of human-specific repetitive elements [PDF]
, 2013 At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of
Barbosa-Morais, Nuno L. +15 more
core +1 more source
Cell Reports, 2020 Summary: circSLC45A4 is the main RNA splice isoform produced from its genetic locus and one of the highest expressed circRNAs in the developing human frontal cortex.
Christin Suenkel +4 more
doaj +1 more source
DNA methylation and regulatory elements during chicken germline stem cell differentiation [PDF]
, 2018 Funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.The production of germ cells in vitro would open important new avenues for stem biology and human medicine, but the mechanisms of germ cell differentiation are not well ...
Cai, Wentao +8 more
core +2 more sources