Information capacity of genetic regulatory elements
, 2007 Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need to perform ...
A. P. Gasch +12 more
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Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD [PDF]
, 2015 Background: Facioscapulohumeral dystrophy (FSHD) is commonly associated with contraction of the D4Z4 macro-satellite repeat on chromosome 4q35 (FSHD1) or mutations in the SMCHD1 gene (FSHD2).
B Mifsud +26 more
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Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
Cell Reports, 2015 Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human ALU repeats, sequence features that promote exon circularization are largely unknown. We
Andranik Ivanov +10 more
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A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)
Diseases, 2022 Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific.
Georgios S. Markopoulos
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Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq. [PDF]
, 2019 One of the primary aims of the Functional Annotation of ANimal Genomes (FAANG) initiative is to characterize tissue-specific regulation within animal genomes.
Bellone, Rebecca R +9 more
core +2 more sources
MicroRNAs as regulatory elements in psoriasis
Open Medicine, 2016 Abstract Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis.
Liu Yuan, Liu Quanzhong
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CLARE: Cracking the LAnguage of Regulatory Elements [PDF]
Bioinformatics, 2011 AbstractSummary: CLARE is a computational method designed to reveal sequence encryption of tissue-specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements.
Leila Taher +2 more
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Super-Enhancers Dysregulations in Hematological Malignancies
Cells, 2022 Hematological malignancies affecting either the lymphoid or the myeloid lineages involve epigenetic mutations or dysregulation in the majority of cases.
Yannis Belloucif, Camille Lobry
doaj +1 more source
Reporter constructs with low background activity utilizing the cat gene [PDF]
, 1992 Reporter plasmids utilizing the cat gene for the analysis of promoter and enhancer sequences in vertebrate cells, were constructed. These plasmids minimize the background of transcription derived from cryptic promoters or cryptic regulatory elements ...
Andrea Schmidt +11 more
core +1 more source
Regression trees for regulatory element identification [PDF]
Bioinformatics, 2004 Abstract Motivation: The transcription of a gene is largely determined by short sequence motifs that serve as binding sites for transcription factors. Recent findings suggest direct relationships between the motifs and gene expression levels. In this work, we present a method for identifying regulatory motifs.
Tu Minh Phuong +2 more
openaire +3 more sources