Results 51 to 60 of about 1,489,667 (310)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner

EMBO Reports
The circular RNA (circRNA) Cdr1as is conserved across mammals and highly expressed in neurons, where it directly interacts with microRNA miR-7. However, the biological function of this interaction is unknown.
Cledi A Cerda-Jara, Seung Joon Kim, Gwendolin Thomas, Zohreh Farsi, Grygoriy Zolotarov, Giuliana Dube, Aylina Deter, Ella Bahry, Elisabeth Georgii, Andrew Woehler, Monika Piwecka, Nikolaus Rajewsky   +11 more
doaj   +1 more source

Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation

Frontiers in Genome Editing, 2023
DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han, Hong Jo Lee, Tae Hyun Kim, Tae Hyun Kim   +3 more
doaj   +1 more source

INCLUSive : a web portal and service registry for microarray and regulatory sequence analysis [PDF]

, 2003
INCLUSive is a suite of algorithms and tools for the analysis of gene expression data and the discovery of cis-regulatory sequence elements. The tools allow normalization, filtering and clustering of microarray data, functional scoring of gene clusters ...
Coessens, Bert, Thijs, Gert, Aerts, Stein, Marchal, Kathleen, De Smet, Frank, Engelen, Kristof, Glenisson, Patrick, Moreau, Yves, Mathys, Janick, De Moor, Bart   +9 more
core   +3 more sources

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

The history and function of a circular RNA

Nature Communications
Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671.
Cledi A. Cerda-Jara, Flavia Scoyni, Grygoriy Zolotarov, Poojashree Bhaskar, Daniel León-Periñán, Jørgen Kjems, Nikolaus Rajewsky   +6 more
doaj   +1 more source

Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

Cell Reports
Summary: The acidic metabolic byproducts within the tumor microenvironment (TME) hinder T cell effector functions. However, their effects on T cell infiltration remain largely unexplored.
Zhe Wang, Jingzhe Shang, Yajing Qiu, Hongcheng Cheng, Mengyuan Tao, Ermei Xie, Xin Pei, Wenhui Li, Lianjun Zhang, Aiping Wu, Guideng Li   +10 more
doaj   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus [PDF]

, 2017
Cis-regulatory modules contain multiple transcription factor (TF)-binding sites and integrate the effects of each TF to control gene expression in specific cellular contexts.
Chen, Yujie, Choudhary, Mayank N.K., Cohen, Barak A, Fiore, Christopher, Hughes, Ava, Maricque, Brett, Ngo, Duc, Paguntalan, Asia, Pandey, Manishi, Pehrsson, Erica, Ray, Tammy, Sundaram, Vasavi, Udawatta, Methma, Wang, Ting, Xing, Xiaoyun   +14 more
core   +2 more sources

Evolution of hemoglobin loci and their regulatory elements [PDF]

Blood Cells, Molecules, and Diseases, 2018
Across the expanse of vertebrate evolution, each species produces multiple forms of hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple hemoglobins are encoded in two globin gene clusters in almost all species. One globin gene cluster, linked to the gene NPRL3, is preserved in all vertebrates, including a gene ...
Sjaak Philipsen, Ross C. Hardison
openaire   +2 more sources