Results 41 to 50 of about 2,215,149 (300)
Plant Biotechnology Journal, 2017 Summary Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is severely damaging to the global citrus industry. Targeted editing of host disease‐susceptibility genes represents an interesting and potentially durable alternative in plant ...
A. Peng +7 more
semanticscholar +1 more source
Synthetic promoter design in Escherichia coli based on a deep generative network
Nucleic Acids Research, 2020 Promoter design remains one of the most important considerations in metabolic engineering and synthetic biology applications. Theoretically, there are 450 possible sequences for a 50-nt promoter, of which naturally occurring promoters make up only a ...
Ye Wang +5 more
semanticscholar +1 more source
Promoting Adipose Specificity: The Adiponectin Promoter [PDF]
Endocrinology, 2010 In the modern obesogenic environment, obesity, insulin resistance and type 2 diabetes mellitus are becoming a global epidemic. At the organismal level, obesity is causally linked to the metabolic dysfunction of energy balance and homeostasis in the adipose tissue (reviewed in Refs. 1–3).
openaire +2 more sources
Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]
, 2011 Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan +4 more
core +1 more source
Carbon TrendsIn response to the escalating demand for cleaner energy sources, this study investigates the potential of carefully selected functionalized graphene-based materials for enhancing hydrogen sulphide (H2S) removal in fuel streams, utilizing semi-empirical ...
Toyese Oyegoke +3 more
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In silico analysis of transcription factor binding sites in promoters of germin-like protein genes in rice [PDF]
Archives of Biological Sciences, 2016 Germins (GERs) and germin-like proteins (GLPs) play important roles in responses to various stresses; however, their function is still not fully understood. Significant insight into their function can be obtained by analyzing their promoters. In
Ilyas Muhammad +2 more
doaj +1 more source
GC-selective DNA-binding antibiotic, Mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis [PDF]
, 2006 The primary role of the Hdm2/Mdm2 oncoprotein is to regulate the levels and activity of the transcription factor p53. Hdm2 synthesis is itself tightly controlled and, as demonstrated by a recently described SNP (SNP309) in the hdm2-P2 promoter, minor ...
Blaydes, J.P., Darley, M., Phillips, A.
core +2 more sources
Genome Biology, 2015 Arabidopsis mutants produced by constitutive overexpression of the CRISPR/Cas9 genome editing system are usually mosaics in the T1 generation. In this study, we used egg cell-specific promoters to drive the expression of Cas9 and obtained non-mosaic T1 ...
Zhiping Wang +6 more
semanticscholar +1 more source
Methylation status of hypothalamic Mkrn3 promoter across puberty
Frontiers in Endocrinology, 2023 Makorin RING finger protein 3 (MKRN3) is an important factor located on chromosome 15 in the imprinting region associated with Prader-Willi syndrome. Imprinted MKRN3 is expressed in hypothalamic regions essential for the onset of puberty and mutations in
Pavlos Fanis +11 more
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