Results 11 to 20 of about 595,995 (298)

Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi [PDF]

BMC Gastroenterology, 2006
Background Hepatitis B virus (HBV) genotypes have distinct geographic distribution. Moreover, much genetic variability has been described in the precore (PC) and basal core promoter (BCP) regions of the HBV genome.
Naqvi Syed, Siddiqui Arif, Muzaffar Rana, Abbas Zaigham, Rizvi Syed   +4 more
doaj   +3 more sources

Genetic variant in theHSPB1 promoter region impairs the HSP27 stress response [PDF]

Human Mutation, 2007
The 27 kDa heat shock protein 1 (HSP27) is a member of the ubiquitously expressed small heat shock protein family and has pleiotropic cytoprotective functions. Since HSP27 may act as a motor neuron survival factor, we analyzed the genetic contribution of the human HSPB1 gene (HSPB1) to the etiology of amyotrophic lateral sclerosis (ALS). In a cohort of
Dierick, Ines, Irobi-Devolder, Joy, Janssens, Sophie, Theuns, Jessie, Lemmens, Robin, Jacobs, An, Corsmit, Ellen, Hersmus, Nicole, van den Bosch, Ludo, Robberecht, Wim, De Jonghe, Peter, Van Broeckhoven, Christine, Timmerman, Vincent   +12 more
openaire   +3 more sources

Clinical Implications of Genetic Variation in the Serotonin Transporter Promoter Region [PDF]

The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
To determine the state of the art in understanding the role of genetic variation in the serotonin transporter (5-HTT) promoter region (5-HTTLPR) in the development of a depressive episode and in its response to treatment.PubMed and Ovid were used to search for articles published prior to December 2007 utilizing the key words serotonin transporter, 5 ...
Nicole S, Luddington, Anitha, Mandadapu, Margaret, Husk, Rif S, El-Mallakh   +3 more
openaire   +2 more sources

Genetic analysis of the promoter region of the Bacillus subtilis alpha-amylase gene [PDF]

Journal of Bacteriology, 1989
The amyR2 allele of the Bacillus subtilis alpha-amylase cis-regulatory region enhances production of amylase and transcription of amyE, the structural gene, by two- to threefold over amyR1. The amylase gene bearing each of these alleles was cloned on plasmids of about 10 to 15 copies per chromosome. Transcription of the cloned amylase gene by each amyR
M J, Weickert, G H, Chambliss
openaire   +2 more sources

Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer

Pharmaceuticals, 2021
E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation
Gianluca Tedaldi, Chiara Molinari, Celina São José, Rita Barbosa-Matos, Ana André, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Luca Saragoni, Paolo Morgagni, Francesca Rebuzzi, Matteo Canale, Sara Pignatta, Elisa Ferracci, Giovanni Martinelli, Guglielmina Nadia Ranzani, Carla Oliveira, Daniele Calistri, Paola Ulivi   +18 more
doaj   +1 more source

Transcriptional analysis of the human PAX9 promoter

Journal of Applied Oral Science, 2010
OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida, Simone Caixeta de Andrade, Cristiane Pereira Borges Saito, Liza Lima Ramenzoni, Sergio Roberto Peres Line   +4 more
doaj   +1 more source

Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells

Frontiers in Genetics, 2018
The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene.
Keiko Tano, Rena Onoguchi-Mizutani, Fouzia Yeasmin, Fumiaki Uchiumi, Yutaka Suzuki, Tetsushi Yada, Nobuyoshi Akimitsu   +6 more
doaj   +1 more source

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Communications Biology, 2023
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman   +7 more
doaj   +1 more source

Variation in the flowering time orthologs BrFLC and BrSOC1 in a natural population of Brassica rapa. [PDF]

, 2015
Understanding the genetic basis of natural phenotypic variation is of great importance, particularly since selection can act on this variation to cause evolution.
Franks, Steven J, Jordan, Kevin P, Lalchan, Rebecca, Litt, Amy, Nowogrodzki, Anna, Perez-Sweeney, Beatriz, Strahl, Maya, Weber, Jennifer J   +7 more
core   +2 more sources

Genetic Dissection of the Light-InduciblecarQRSPromoter Region ofMyxococcus xanthus [PDF]

Journal of Bacteriology, 2004
ABSTRACTInMyxococcus xanthusphotoprotective carotenoids are produced in response to illumination due to regulated expression of carotenoid biosynthesis genes at two loci. Induction of the carotenogenesis regulon is dependent on expression of thecarQRSoperon.
David E, Whitworth, Samantha J, Bryan, Andrew E, Berry, Simon J, McGowan, David A, Hodgson   +4 more
openaire   +2 more sources