Results 11 to 20 of about 552,746 (191)
Genetic analysis of the promoter region of the Bacillus subtilis alpha-amylase gene [PDF]
Journal of Bacteriology, 1989 The amyR2 allele of the Bacillus subtilis alpha-amylase cis-regulatory region enhances production of amylase and transcription of amyE, the structural gene, by two- to threefold over amyR1. The amylase gene bearing each of these alleles was cloned on plasmids of about 10 to 15 copies per chromosome. Transcription of the cloned amylase gene by each amyR
M J Weickert, Glenn H. Chambliss
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Neuroscience Letters, 2023 Mutations in the ATG genes have been related to impair autophagic function, contributing to the sporadic onset of Parkinsońs Disease (PD). However, scarce studies have been performed about ins/del within the regulatory domains of the autophagy genes in sporadic PD patients. This study was aimed to found ins/del within part of the crucial core autophagy
Gómez Martín, Ana María +4 more
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Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation
Frontiers in Genome Editing, 2023 DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han +3 more
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Insights into alpha-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin. [PDF]
PLoS ONE, 2014 Alpha-hemolysin (Hla) is a major virulence factor in the pathogenesis of Staphylococcus aureus infection, being active against a wide range of host cells. Although hla is ubiquitous in S.
Ana Tavares +8 more
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Pharmaceuticals, 2021 E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation
Gianluca Tedaldi +18 more
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Scientific Reports, 2021 We investigated the association between genetic variants in the histone modification regions and the prognosis of lung adenocarcinoma after curative surgery. Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The
Hyo-Gyoung Kang +20 more
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Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer [PDF]
BioMed Research International, 2017 Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related
Jiaping Chen +9 more
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BMC Biotechnology, 2020 Background Promoters that confer expression in fruit tissues are important tools for genetic engineering of fruit quality traits, yet few fruit-specific promoters have been identified, particularly for citrus fruit development.
Kasturi Dasgupta +6 more
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Transcriptional analysis of the human PAX9 promoter
Journal of Applied Oral Science, 2010 OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida +4 more
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Functional analysis of recurrent CDC20 promoter variants in human melanoma
Communications Biology, 2023 Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy +7 more
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