Results 61 to 70 of about 552,746 (191)

Relationship between promoter sequence and its strength in gene expression [PDF]

Eur. Phys. J. E 37 (2014) 86, 2014
In this study, through various tests one theoretical model is presented to describe the relationship between promoter strength and its nucleotide sequence. Our analysis shows that, promoter strength is greatly influenced by nucleotide groups with three adjacent nucleotides in its sequence.
arxiv   +1 more source

Association Between Promoter Polymorphisms in CD46 and CD59 in Kidney Donors and Transplant Outcome

Frontiers in Immunology, 2018
Complement regulating proteins, including CD46, CD55, and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be involved in accommodation.
Laura A. Michielsen, Arjan D. van Zuilen, Tineke Kardol-Hoefnagel, Marianne C. Verhaar, Henny G. Otten   +4 more
doaj   +1 more source

Correlations between promoter activity and its nucleotide positions in spacing region [PDF]

arXiv, 2015
Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide sequence of promoter has great influence on gene expression strength, or promoter activity.
arxiv  

Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy

American Journal of Respiratory and Critical Care Medicine, 2009
Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases.The genetic contribution of CHI3L1 gene to atopic susceptibility was investigated using an integrated ...
Sung Hee Lee, Chun Geun Lee, Jack A. Elias, Kyung Won Kim, So Won Kim, Min Goo Lee, Kyu-Earn Kim, Kyung Hwan Kim, Ji Hyun Lee, Myung Hyun Sohn   +9 more
openaire   +4 more sources

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Nature Communications, 2018
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney   +12 more
doaj   +1 more source

Population genetic consequences of the Allee effect and the role of offspring-number variation [PDF]

arXiv, 2013
A strong demographic Allee effect in which the expected population growth rate is negative below a certain critical population size can cause high extinction probabilities in small introduced populations. However, many species are repeatedly introduced to the same location and eventually one population may overcome the Allee effect by chance.
arxiv  

Semantic-based Distance Approaches in Multi-objective Genetic Programming [PDF]

arXiv, 2020
Semantics in the context of Genetic Program (GP) can be understood as the behaviour of a program given a set of inputs and has been well documented in improving performance of GP for a range of diverse problems. There have been a wide variety of different methods which have incorporated semantics into single-objective GP.
arxiv  

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Experimental and Molecular Medicine, 2020
Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H.
Xianke Zeng, Hye Kyung Lee, Chaochen Wang, Precious Achikeh, Chengyu Liu, Lothar Hennighausen   +5 more
doaj   +1 more source

Competitive binding of transcription factors drives Mendelian dominance in regulatory genetic pathways [PDF]

arXiv, 2016
We report a new mechanism for allelic dominance in regulatory genetic interactions that we call binding dominance. We investigated a biophysical model of gene regulation, where the fractional occupancy of a transcription factor (TF) on the cis-regulated promoter site it binds to is determined by binding energy (-{\Delta}G) and TF dosage.
arxiv  

Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk. [PDF]

PLoS Genetics, 2007
Common genetic variation could alter the risk for developing bladder cancer. We conducted a large-scale evaluation of single nucleotide polymorphisms (SNPs) in candidate genes for cancer to identify common variants that influence bladder cancer risk.
Montserrat García-Closas, Núria Malats, Francisco X Real, Meredith Yeager, Robert Welch, Debra Silverman, Manolis Kogevinas, Mustafa Dosemeci, Jonine Figueroa, Nilanjan Chatterjee, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Cristiane Murta-Nascimento, Nathaniel Rothman, Stephen J Chanock   +16 more
doaj   +1 more source