Results 71 to 80 of about 552,746 (191)
Genetic polymorphisms in the 5' flanking region of glutathione S-transferase P1 affect promoter methylation [PDF]
Breast Cancer Research, 2005 Glutathione-S-transferase P1 (GSTP1) is involved in thiol-mediated detoxification and breakdown of reactive oxygen species created by anticancer drug exposure. GSTP1 is also an inhibitor of c-Jun N-terminal kinase 1, a kinase involved in stress response, apoptosis and cellular proliferation.
A-L Børresen-Dale +7 more
openaire +2 more sources
Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma
Infectious Agents and Cancer, 2017 Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alterations in the human genome.
Francesca Pezzuto +3 more
doaj +1 more source
Single Nucleotide Polymorphisms: A Deep Consideration of Protein Sequence Variation [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī YazdIntroduction: Human genome consists of the three billion base pairs that has about one percent of genetic variation from one person to another، which determines physical، psychological، and susceptibility to diseases. Among the types of genetic diversity,
Majid Marzban Sarnaghi +3 more
doaj
Molecular Oncology, 2019 Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for disease monitoring in melanoma.
Leslie Calapre +14 more
doaj +1 more source
Association analysis identifies
BMC Medical Genetics, 2011 Background Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis.
Birnbaum Ramon Y +8 more
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Multiple Changes Underlie Allelic Divergence of CUP2 Between Saccharomyces Species
G3: Genes, Genomes, Genetics, 2019 Under the model of micromutationism, phenotypic divergence between species is caused by accumulation of many small-effect changes. While mapping the causal changes to single nucleotide resolution could be difficult for diverged species, genetic ...
Xueying C. Li, Justin C. Fay
doaj +1 more source
Adaptive evolution of transcription factor binding sites [PDF]
BMC Evolutionary Biology 4(1):42 (2004), 2003 The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in the evolution of complex regulatory networks. We study a theoretical model for the sequence evolution of binding
arxiv
DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
PLoS ONE, 2017 The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes.
Mads Dyrvig +6 more
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Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits [PDF]
arXiv, 2010 Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic stabilization. Non-genetic perturbations can thus initiate evolutionary innovation.
arxiv
Gut Microbes ReportsBacteroidaceae is a prominent family in the human gut microbiota. The bacteria within this family are characterized by phase variable regulation of diverse surface structures, such as capsular polysaccharides and outer membrane proteins.
Emmanuel Munyeshyaka +5 more
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