Results 121 to 130 of about 466,642 (309)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The composition of constitutive promoters.

, 2014
[A] The known consensus sequences of RpoD-dependent promoter, TTGAAC (-35) and TATAAT (-10) separated by 17 plus/minus 2 bp, were searched for all type-A (177) and type-B (315) spacers (see Experimental Procedure for the analysis method).
Akira Ishihama (218938), Kan Tanaka (11731), Yukiko Yamazaki (60362), Tomohiro Shimada (218931)   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Ownership concentration and dividend distribution decision in a bank: Does competition matter?

Cogent Business & Management
This research aims to probe the mutual association between ownership concentration (OC), and the dividend policy (DP) of banks in India. Moreover, the study also determines the influence of competition on OC’s and dividend.
Shailesh Rastogi, Aman Pushp, Jagjeevan Kanoujiya, Bhakti Agarwal   +3 more
doaj   +1 more source

Dynamic modulation of enhancer‐promoter and promoter‐promoter connectivity in gene regulation

BioEssays
AbstractEnhancers are short segments of regulatory DNA that control when and in which cell‐type genes should be turned on in response to a variety of extrinsic and intrinsic signals. At the molecular level, enhancers serve as a genomic scaffold that recruits sequence‐specific transcription factors and co‐activators to facilitate transcription from ...
Shiho Makino, Takashi Fukaya
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Genome-wide mapping of the

iScience
Summary: Galleria mellonella is an emerging experimental model, but its current genome annotation lacks transcription start site (TSS) information. Because TSS annotation is essential for understanding transcriptional regulation, we used low quantity ...
Imad Abugessaisa, Mickey Konings, Ri-ichiroh Manabe, Michihira Tagami, Jessica Severin, Akira Hasegawa, Tsugumi Kawashima, Hiroko Kinoshita, Shohei Noma, Chitose Takahashi, Annelies Verbon, Yasushi Okazaki, Wendy W.J. van de Sande, Takeya Kasukawa   +13 more
doaj   +1 more source

Designs of cloned pNKCC2, NPT2a, and AQP2 promoters.

, 2017
a. Three different NKCC2 promoters used in this study. Transgene expression patterns were compared among the constructs, using these promoters. b. NPT2a promoter. c. AQP2 promoter.
Toru Ogasawara (266984), Ung-il Chung (34003), Yoshifuru Tamura (770149), Tatsuo Shimosawa (514019), Toshiyuki Ikeda (35392), Shigeru Shibata (770151), Shunya Uchida (770154), Sumiyo Watanabe (2050396), Taku Saito (35393), Nobuchika Suzuki (3808963), Masaomi Nangaku (313494)   +10 more
core   +1 more source