Results 101 to 110 of about 466,642 (309)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Developing a minimally invasive gene therapy for multiple sclerosis
Molecular Therapy: Methods & Clinical DevelopmentMultiple sclerosis (MS) is a neurological disease characterized by demyelinating lesions in the CNS. This study investigated whether a minimally invasive adeno-associated virus (AAV) vector (AAV.PHP.eB) can direct transgene expression in CNS cell types ...
Paul J.H. Nijhuis +6 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Applied MicrobiologyCellulosic biomass is considered an important and sustainable source of renewable energy, which needs a complex mixture of different enzymes for its degradation. After amylase, cellulases are the second most important enzymes, gain more importance due to
Nazish Muzaffar +6 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Promotion and promotion review in Canadian universities
Revue de droit. Université de Sherbrooke, 1985 Il y a peu de doute que, compte tenu du nombre restreint de nouvelles nominations effectuées dans les collèges et les universités canadiennes au cours des dernières années, l’attention des intervenants s’est déplacée de la question de la permanence pour porter sur celle de la promotion.
openaire +1 more source
Microarray analysis of DNA methylation status of miRNA promoters.
, 2013 A, multidimensional scaling of pairwise distances derived from DNA methylation level of all miRNA promoter regions from all samples analyzed by microarray. CCL – cancer cell lines. B, same as A, but for in vitro grown cells only.
Bernard W. Futscher (103582) +3 more
core +1 more source
Diversity of core promoter elements comprising human bidirectional promoters [PDF]
, 2008 Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Mary Yang +3 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PSMMs of two promoters/samples.
, 2016 PSMMs of two promoters/samples.
Kouser K. (3569339) +3 more
core +1 more source