Results 51 to 60 of about 236,086 (290)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Desperately Seeking a Communicative Approach: English Pronunciation in a Sample of French and Polish Secondary School Textbooks [PDF]

, 2014
The first part of this paper analyses pronunciation exercises in a representative sample of textbooks from each country. Pronunciation exercises were classified based on the degree to which they mobilize communicative abilities, according to the five ...
Alice Henderson, Anna Jarosz, Bradford, Bradford, Bragger, Bragger, Bruillard, Bruillard, Burgess, Burgess, Canale, Canale, Carney, Carney, Catford, Catford, Celce, Celce, Council, Council, Derwing, Derwing, Derwing, Derwing, Foote, Foote, Frost, Frost, Gray, Gray, Henderson, Henderson, Hickey, Hickey, Hymes, Hymes, Iivonen, Iivonen, Jenkins, Jenkins, Labov, Labov, Martin, Martin, Munro, Munro, Munro, Munro, Rogerson, Rogerson, Seidlhofer, Seidlhofer, Seidlhofer, Seidlhofer, SOFRES, SOFRES, Spiewak, Spiewak, Swan, Swan, Szpyra, Szpyra, Tergujeff, Tergujeff   +63 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Podcasting: An Effective Tool for Honing Language Students’ Pronunciation? [PDF]

Language Learning and Technology, 2001
This paper reports on an investigation of podcasting as a tool for honing pronunciation skills in intermediate language learning. We examined the effects of using podcasts to improve pronunciation in second language learning and how students’ attitudes ...
Lara Ducate, Lara Lomicka
doaj  

Experimental research on English vowel errors analysis

SHS Web of Conferences, 2016
Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software.
Huang Qiuhua
doaj   +1 more source

Training novel phonemic contrasts: a comparison of identification and oddity discrimination training [PDF]

, 2009
High Variability Pronunciation Training (HVPT) is a highly successful alternative to ASR-based pronunciation training. It has been demonstrated that HVPT is effective in teaching the perception of non-native phonemic contrasts, and that this skill ...
Handley, Zöe, Moore, Dave, Sharples, Mike   +2 more
core  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Exploring English pronunciation teaching practices at Vietnamese primary schools

Ho Chi Minh City Open University Journal of Science - Social Sciences
Pronunciation is a crucial factor in the success of English conversations. However, understanding pronunciation teaching methods and the challenges teachers face in EFL countries like Vietnam remains limited, with little research conducted in Vietnamese ...
Ngan Thi Phuong Phan, Ngoc Thi Nhu Truong, Nhan Tu Nguyen   +2 more
doaj   +1 more source

Japanese native speakers' perception of Brawijaya University Japanese Language Education Students' intonation pronunciation of Aizuchi Soudesuka

Japanese Research on Linguistics, Literature, and Culture, 2023
This study uses a qualitative approach by presenting data descriptively. This study aims to determine how Japanese native speakers perceive Japanese learners' soudesuka’s intonation pronunciation. Three Japanese native speakers participated in this study
Naura Rohadatul 'Aisy
doaj   +1 more source

The English pronunciation teaching in Europe survey: selected results [PDF]

, 2012
The results of EPTiES reveal interesting phenomena across Europe, despite shortcomings in terms of construction and distribution. For example, most respondents are non-native speakers of English and the majority of them rate their own mastery of English ...
Cunnigham, Una, Cunningham, Una, Curnick, Lesley, Frost, Dan, Henderson, Alice, Kautzsch, Alexander, Kirkova-Naskova, Anastazija, Levey, David, Murphy, Deirdre, Tergujeff, Elina, Waniek-Klimczak, Ewa   +10 more
core   +3 more sources