Results 81 to 90 of about 242,626 (288)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Advanced EFL learners' beliefs about language learning and teaching: a comparison between grammar, pronunciation, and vocabulary [PDF]

, 2011
This paper reports on the results of a study exploring learners’ beliefs on the learning and teaching of English grammar, pronunciation and vocabulary at tertiary level.
Alexander A. Patricia, Azar Betty, Bacon M. Susan, Barcelos F. Ana Maria, Bernat Eva, Brown V. Alan, Brumfit J. Christopher, Carifio James, Cenoz Jasone, Cotterall Sara, Davies Alan, Doughty Catherine, Ellen Simon, Ellis Rod, Escudero, Paola and Mike Sharwood Smith, Goethals Michaël, Horwitz K. Elaine, Horwitz K. Elaine, Hunt Alan, Jamieson Susan, Jenkins Jennifer, Jenkins Jennifer, Kalaja Paula, Laufer Batia, Mantle-Bromley Corinne, Miriam Taverniers, Mori Yoshiko, Oxford L. Rebecca, Raymond Elliott A., Richards C. Jack, Shawn Loewen, Thompson Irene, Trofimovich Pavel, Tumposky R. Nancy, Wenden L Anita, Wenden L Anita, Wenden L Anita, Yang Nae-Dong   +37 more
core   +1 more source

Native-speaker and English as a lingua franca pronunciation norms: English majors’ views

Studies in Second Language Learning and Teaching, 2011
Within the communicative approach to English as a foreign language (EFL) teaching, the aims of instruction are primarily to enable learners to communicate; hence, functional and communicative intelligibility has become the goal of pronunciation training.
Aleksandra Wach
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

AN ERROR ANALYSIS OF PHONEMESIN READING – ALOUD ACTIVITY \ud PRODUCED BY THE FIRSTSEMESTER STUDENTS OF ENGLISH \ud DEPARTMENT, MUHAMMADIYAH UNIVERSITY OF MALANG [PDF]

, 2007
This study was conducted to analyze the error or phonemes in reading aloud activity produced by the first semester students of English Department of Muhammdiyah University of Malang. The design that the researcher used is descriptive qualitative research.
SUSILAWATI, FITRI
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

The Effect of Popular English Song and English Movie on Students\u27 Pronunciation at MTsN 3 Jakarta [PDF]

, 2016
This research aims to discover whether the English popular songs and movies are an effective media in enhancing and improving students\u27 pronunciation. The subjects in the study were involving 62 students from grade 8 in MTsN 3 Jakarta and were divided
Tanjung, K. S. (Khoiriyah)
core  

Orthographic input and phonological representations in learners of Chinese as a foreign language. [PDF]

, 2006
This paper provides evidence that the second language orthographic input affects the mental representations of L2 phonology in instructed beginner L2 learners. Previous research has shown that orthographic representations affect monolinguals' performance
Bassetti, Benedetta
core   +1 more source