Results 31 to 40 of about 2,666 (246)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Teaching Experience and Instructional Context: How They Shape English Teachers’ Beliefs and Practices in Pronunciation Instruction

SAGE Open
This study examines the beliefs and practices of English teachers in China regarding pronunciation instruction, with a focus on how teaching experience and instructional context shape their beliefs and practices.
Xiaojiao Xue, Yuqing Zhong, Orooba Mushtaq, Min Zhou   +3 more
doaj   +1 more source

AI integration in pronunciation instruction: Insights from secondary school EFL teachers

Technology in Language Teaching & Learning
There has been growing interest in the potential of artificial intelligence (AI) in language education. However, little research has explored its application in pronunciation instruction.
Anh Que Chung
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Unlocking potential: Integrating pronunciation into business instruction to inspire students and strengthen content teachers

Studies in English Language and Education
Integrating content and language instruction has gained popularity worldwide because it allows students to improve their content knowledge while concurrently honing their language skills.
Budsaba Kanoksilpatham, Chongrug Pariwatnanont   +1 more
doaj   +1 more source

EFL Pronunciation Teaching: A Theoretical Review [PDF]

Journal of Applied Linguistics, 2010
This study aims to represent the developing status of pronunciation teaching and presents the current perspectives on pronunciation learning and teaching, coupled with innovative approaches and techniques/activities.
Hamid Nikbakht
doaj  

The Challenges, Methods and Results of Teaching GB Pronunciation to Slovene EFL Students

ELOPE, 2019
The paper presents and discusses the results of a study whose main purpose was to test the oral production of General British (GB) sounds in connected speech by Slovene BA students of English.
Smiljana Komar
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Assessing instructional effects of proficiency-level EFL pronunciation teaching under a connected speech-based approach

Studies in Second Language Learning and Teaching, 2014
This article discusses the assessment of pronunciation instruction under a new approach to pronunciation teaching centered on the role of connected speech in the prosodic system of English.
Sasha S. Euler
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source