Results 41 to 50 of about 94,443 (308)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transfer, similarity or lack of awareness? inconsistencies of German learners in the pronunciation of lot, thought, strut, palm and bath [PDF]

, 2012
The current study presents acoustic analyses of non-high back vowels and low central vowels in the lexical sets LOT, THOUGHT, STRUT, PALM and BATH as pronounced by German learners of English.
Kautzsch, Alexander
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Apps for developing pronunciation in English as an L2

Revista X, 2021
The goal of pronunciation teaching should be to enable learners to develop intelligible pronunciation and, in order to do this, it is important to teach perception and production of the most relevant segmental and suprasegmental features of pronunciation,
Luana Garbin Baldissera, Celso Henrique Soufen Tumolo   +1 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Improving L2 pronunciation inside and outside the classroom

Ilha do Desterro, 2018
Spanish/Catalan learners of English as a Foreign Language (EFL) attended a formal instruction (FI) period combined with explicit pronunciation instruction, which consisted of theoretical and practical approaches to English segmental phonetics as well as
Angélica Carlet, Hanna Kivistö-de Souza   +1 more
doaj   +1 more source

An Automatic Pronunciation Error Detection and Correction Mechanism in English Teaching Based on an Improved Random Forest Model

Journal of Electrical and Computer Engineering, 2022
Teachers in traditional English classes focus more on writing and grammar instruction, while oral language instruction is neglected. In exam-oriented education, most Chinese students can master English written test skills, but only a few students can ...
Yuhua Dai
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Teaching Experience and Instructional Context: How They Shape English Teachers’ Beliefs and Practices in Pronunciation Instruction

SAGE Open
This study examines the beliefs and practices of English teachers in China regarding pronunciation instruction, with a focus on how teaching experience and instructional context shape their beliefs and practices.
Xiaojiao Xue, Yuqing Zhong, Orooba Mushtaq, Min Zhou   +3 more
doaj   +1 more source

AI integration in pronunciation instruction: Insights from secondary school EFL teachers

Technology in Language Teaching & Learning
There has been growing interest in the potential of artificial intelligence (AI) in language education. However, little research has explored its application in pronunciation instruction.
Anh Que Chung
doaj   +1 more source