Results 31 to 40 of about 94,443 (308)

Pronunciation instruction in the context of world English: exploring university EFL instructors’ perceptions and practices

Humanities & Social Sciences Communications
Teaching a foreign language requires instructors to be knowledgeable about and capable of providing instruction that facilitates their students’ ability to understand, speak, read, and write the new language. However, as established within the literature,
Asma Almusharraf
doaj   +1 more source

Native-speaker and English as a lingua franca pronunciation norms: English majors’ views

Studies in Second Language Learning and Teaching, 2011
Within the communicative approach to English as a foreign language (EFL) teaching, the aims of instruction are primarily to enable learners to communicate; hence, functional and communicative intelligibility has become the goal of pronunciation training.
Aleksandra Wach
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pronunciation instruction and syllabic-pattern discrimination [PDF]

DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2011
The present research is an investigation of the role played by pronunciation instruction in the discrimination of English CVC and CVCV syllabic patterns in word-final position. The participants of this study were two groups of Brazilian learners (beginners): the control group (10 students), and the experimental group (12 students).
openaire   +3 more sources

“I Understood You, But There was This Pronunciation Thing…”: L2 Pronunciation Feedback in English/French Tandem Interactions [PDF]

, 2013
We hope that our data brings a valuable and fairly unique contribution to SLA research, helping to establish which errors get corrected and how it may have implications for setting priorities in L2 pronunciation ...
Brammerts, Brammerts, Brammerts, Brammerts, Céline Horgues, Doughty, Doughty, Ellis, Ellis, Ellis, Ellis, Gass, Gass, Horgues, Horgues, James, James, Jenkins, Jenkins, Kramsch, Kramsch, Lyster, Lyster, Lyster, Lyster, Mackey, Mackey, Mackey, Mackey, Markham, Markham, Ritchie, Ritchie, Rourke, Rourke, Sato, Sato, Schmidt, Schmidt, Sheen, Sheen, Sylwia Scheuer, Tatawy, Tatawy   +43 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Contrastive vs Non-Contrastive Meta-Phonetic Input in Teaching Foreign Language Pronunciation

Lidil, 2020
Almost every study on explicit meta-phonetic instruction in teaching foreign language (L2) pronunciation confirms its facilitating effect. However, hardly any studies applying contrastive (L1-L2) meta-phonetic instruction are available so far.
Zdena Kralova, Katarina Nemcokova, Jana Birova   +2 more
doaj   +1 more source

Exploring L1 Transfer in German Learners of English: High Front Vowels, High Back Vowels and the BED/BAD Distinction [PDF]

, 2010
Since the vowel systems of German and English are similar to some extent, German learners of English can be expected to transfer a considerable part of their German vowels to their L2 English.
Kautzsch, Alexander
core   +2 more sources