Results 51 to 60 of about 2,666 (246)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Reflecting on pronunciation instruction in the Polish English classroom: Learners’ perspective

Research in Language
Pronunciation remains a controversial aspect of English instruction, both in theory and practice, with the dichotomy between “nativeness” and “intelligibility” (Levis, 2005) directing research into the exploration of learner and teacher views as to what
Ewa Waniek-Klimczak, Agata Klimczak-Pawlak   +1 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring English pronunciation teaching practices at Vietnamese primary schools

Ho Chi Minh City Open University Journal of Science - Social Sciences
Pronunciation is a crucial factor in the success of English conversations. However, understanding pronunciation teaching methods and the challenges teachers face in EFL countries like Vietnam remains limited, with little research conducted in Vietnamese ...
Ngan Thi Phuong Phan, Ngoc Thi Nhu Truong, Nhan Tu Nguyen   +2 more
doaj   +1 more source

Second language pronunciation: a summary of teaching techniques

Vestnik za Tuje Jezike, 2019
The aim of the paper is to give a critical summary of the traditional and more alternative techniques and activities for pronunciation practice recommended in the literature.
Anastazija Kirkova-Naskova
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Effective learning begins with effective teaching: Teacher cognition and L2 pronunciation instruction

Ilha do Desterro
This article not only serves as the introduction to the special issue “Second language pronunciation: Learning, pedagogy, and teacher education,” but also as a space for the guest editors to reflect on the role of teacher cognition in second language ...
Alison Roberto Gonçalves, Germán Zárate-Sández   +1 more
doaj   +1 more source

Interdental Consonant Sound Errors Made by First Semester Students of English Education of Sanata Dharma University

Vision: Journal for Language and Foreign Language Learning, 2019
This paper investigated factors influencing students’ pronunciation. Pronunciation is one of the important aspects of the learning of English. When mastering English pronunciation, many non-native English speakers have difficulty pronouncing certain ...
Albertus Yordhana Arsanto, Adityo Prawinanto, Barli Bram   +2 more
doaj   +1 more source