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The Proopiomelanocortin System
Annals of the New York Academy of Sciences, 1999ABSTRACT: POMC (31,000 MW) is localized to the pituitary, brain, skin, and other peripheral sites. The particular enzyme profile present within a cell dictates the nature of the hormonal ligand (melanocortin) synthesized and secreted: melanotropic peptides (α‐MSH β‐lipotropin, λ‐MSH), corticotropin (ACTH), several endorphins (e.g., met‐enkephalin ...
M E, Hadley, C, Haskell-Luevano
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Proopiomelanocortin Peptides and Sebogenesis
Annals of the New York Academy of Sciences, 2003Abstract: Previous animal studies have demonstrated that α‐melanocyte‐stimulating hormone (α‐MSH) is a sebotropic hormone in rats and that targeted disruption of melanocortin 5 receptor (MC5‐R) can down‐regulate sebum output in mice. To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and ...
Li, Zhang +4 more
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The Journal of Immunology, 1997
Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Glucocorticoid Regulation of Hypothalamic Proopiomelanocortin
Neuroendocrinology, 1998Although glucocorticoids clearly inhibit proopiomelanocortin (POMC) gene transcription and peptide synthesis in the anterior pituitary, the effects of glucocorticoids on POMC in the hypothalamus are still unclear, even though most POMC neurons in the arcuate nucleus are known to have glucocorticoid receptors.
S L, Wardlaw +2 more
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Proopiomelanocortin-Derived Peptides
Endocrinology and Metabolism Clinics of North America, 1994Cloning of the cDNA of POMC mRNA led to the characterization of the ACTH precursor and established the molecular links between ACTH, beta LPH and gamma LPH, and beta end. Further previously unidentified POMC-derived peptides were also unravelled, including the N-terminal fragment and the JP.
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Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain [PDF]
Brain Research Bulletin, 1984 The immunocytochemical distribution of proopiomelanocortin (POMC) peptides (beta-endorphin, ACTH, alpha-MSH, 16K fragment) was studied in the brain of the rhesus monkey (Macaca mulatta). Some animals were administered colchicine intracerebroventricularly prior to sacrifice to enhance the visualization of perikaryal immunoreactivity.
Suzanne N Haber +2 more
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Regulation of Testicular Proopiomelanocortin Gene Expression*
Endocrinology, 1987The POMC gene is expressed in testicular Leydig cells, but its mRNA is about 150-200 nucleotides shorter in these cells than in the pituitary. For this reason this testicular mRNA has been termed POMC-like mRNA. The purpose of the present study was to define the ontogeny and regulation of POMC gene expression in rat testis.
C L, Chen, M B, Madigan
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Mutations in the Human Proopiomelanocortin Gene
Annals of the New York Academy of Sciences, 2003Abstract: The melanocortin peptides and their receptors represent one of the most complex systems in human endocrinology. Hormonal regulation includes pigmentation, weight maintenance, adrenal function, and exocrine gland secretion via endocrine, paracrine, autocrine, and neurocrine action of melanocortin peptides at five different but homologous ...
Heiko, Krude +2 more
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