Results 231 to 240 of about 19,002 (275)
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Leukemia Inhibitory Factor Regulates Proopiomelanocortin Transcriptiona
Annals of the New York Academy of Sciences, 1998Abstract: Leukemia inhibitory factor (LIF), a pleiotropic cytokine, is expressed in both fetal and adult pituitary tissue, and LIF immunoreactivity is found in functional human pituitary tumors. LIF induces basal, and augments CRH‐induced, POMC mRNA and ACTH secretion from AtT20 cells.
Ray, David W. +2 more
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Molecular Cloning of Lungfish Proopiomelanocortin cDNA
General and Comparative Endocrinology, 1999To investigate the evolution of proopiomelanocortin (POMC) from fish to tetrapods, nucleotide sequence of POMC cDNA from a lobe-finned fish, the African lungfish, was determined. POMC cDNA was prepared from lungfish pituitary glands. The POMC cDNA is composed of 1114 bp, excluding a poly-A tail, and encodes 255 amino acids (aa) including a signal ...
Y, Amemiya +3 more
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Pituitary Proopiomelanocortin Peptides in Mental Disorders
1986Publisher Summary Proopiomelanocortin (POMC) is a long-chain pituitary peptide (PP), the secretion of which is controlled by hypothalamic corticotropin-releasing factor (CRF). POMC is cleaved in the anterior pituitary (AP) into various fragments, including ACTH, β-lipotropin (β-LPH) and β-endorphin (β-E), which under physiological conditions are ...
F. Brambilla +4 more
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1987
Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Genetic modifications of mouse proopiomelanocortin peptide processing
Molecular and Cellular Endocrinology, 2011Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to pigmentation to the regulation of feeding.
Jessica L, Costa +3 more
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Regulation of Proopiomelanocortin Gene Expression in Pituitary
Endocrine Reviews, 1988I. Introduction THE POMC gene encodes the complex precursor to a variety of biologically active, important neuromodulator and endocrine peptides. It is expressed in a variety of tissues in the mammal, but its main site of expression is the pituitary anterior lobe cortocotroph and intermediate lobe melanotroph.
J R, Lundblad, J L, Roberts
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Interrelations between Hypothalamic Somatostatin and Proopiomelanocortin Neurons
Journal of Neuroendocrinology, 1998Somatostatin receptors were visualized by [125I]‐Tyr0‐DTrp8‐somatostatin radioautography on 35% of arcuate neurons containing proopiomelanocortin (POMC) mRNA, as identified by in situ hybridization using a [35S] labelled riboprobe on 5 μm‐thick consecutive sections.
M, Fodor +4 more
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Proopiomelanocortin and the Immune‐Neuroendocrine Connection
Annals of the New York Academy of Sciences, 1999ABSTRACT:This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular understanding of neuroimmunomodulation.
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From Proopiomelanocortin to Cancer
Annals of the New York Academy of Sciences, 1993Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for
M, Mbikay, N G, Seidah, M, Chretien
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Proopiomelanocortin gene expression in man
2003Proopiomelanocortin (POMC) is the polypeptide precursor to ACTH and several other biologically active peptides.
Yves de Keyzer +2 more
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