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Hemorrhage activates proopiomelanocortin neurons in the rat hypothalamus
Brain Research, 2006Severe blood loss lowers arterial pressure through a central mechanism that is thought to include opioid neurons. In this study, we investigated whether hemorrhage activates proopiomelanocortin (POMC) neurons by measuring Fos immunoreactivity and POMC mRNA levels in the medial basal hypothalamus.
Goktalay, GÖKHAN +5 more
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PROOPIOMELANOCORTIN‐DERIVED PEPTIDES IN THE IMMUNE SYSTEM
Clinical Endocrinology, 1985SUMMARYCells of the immune system have recently been recognized as a source of the proopiomelanocortin (POMC)‐derived peptides, ACTH and endorphins, and their receptors. In this review, the nature of the immunoregulatory and hypothalamic signals which elicit the production of these leukocyte‐derived hormones is discussed.
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Proopiomelanocortin and Related Hormones
2010The cutaneous proopiomelanocortin (POMC) system is an important regulatory system, which controls pigmentation, inflammation, and the stress response of the skin. Based on their potent melanotropic effects, selected melanocortin peptides derived from POMC have been tested in the past for their efficacy in vitiligo.
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Proopiomelanocortin and the Melanocortin Peptides
2000The “melanophore stimulants” were discovered about 80 yr ago when, with surgical ablation experiments, the pituitary gland was shown to be involved in the control of skin color of amphibia. The pars intermedia was soon recognized as the origin of the biological principle, then also named “intermedin,” which induced darkening of amphibian skin (for a ...
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Role of Proopiomelanocortin in Preventing Miscarriage.
The Journal of reproductive medicine, 2018To compare the distribution of proopiomelanocortin (POMC) in decidua and placenta samples from missed abortion and voluntary termination cases in order to research the effects in the etiology of missed abortion.Decidual materials were collected from patients who were diagnosed with missed abortion (n=19) and legal voluntary termination cases (n=15 ...
Kemal, Ozbilgin +5 more
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