Results 91 to 100 of about 13,230 (236)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Frontiers in Physiology, 2019
Short QT syndrome variant 1 (SQT1) arises due to gain-of-function mutations to the human Ether-à-go-go-Related Gene (hERG), which encodes the α subunit of channels carrying rapid delayed rectifier potassium current, IKr.
Dominic G. Whittaker, Dominic G. Whittaker, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang, Henggui Zhang   +7 more
doaj   +1 more source

To Pace Or Not To Pace! – Prevention Of Atrial Fibrillation After Coronary Artery Bypass Surgery [PDF]

, 2005
Atrial fibrillation (AF) is a very undesirable, but unfortunately a common arrhythmia following coronary artery bypass graft (CABG) surgery, occurring in up to 40% of patients.
Vora, Amit
core   +2 more sources

Medical treatment of cardiac arrhythmias in Chagas'heart disease [PDF]

, 1995
There are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d ...
De Paola, Angelo Amato Vincenzo, Gondin, Fernando Antonio Aquino, Hara, Vanderlei, Mendonça, Alayde   +3 more
core   +1 more source

Experience with propafenone for the treatment of cardiac arrhythmias in children

The Turkish Journal of Pediatrics, 1990
The aim of this prospective study was to evaluate the efficacy of propafenone in suppressing various arrhythmias in a group of children who were patients in the Pediatric Cardiology Unit of Hacettepe University Children's Hospital. Seven of the 13
A Celiker, S Ozer, S Ozme, S Ozkutlu, O Kahramanyol   +4 more
doaj  

Frequency Analysis of Atrial Fibrillation From the Surface Electrocardiogram [PDF]

, 2004
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Neither the natural history of AF nor its response to therapy are sufficiently predictable by clinical and echocardiographic parameters.
Bollmann, Andreas, Husser, Daniela, Olsson, Bertil, Sornmo, Leif, Stridh, Martin   +4 more
core  

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]

, 2015
AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH, Fraser, JA, Guzadhur, L, Huang, CL-H, Jafferji, DIG, King, JH, Matthews, HR, Salvage, SC   +7 more
core   +2 more sources

Propafenone efficacy in treatment of atrial fibrillation paroxysms: a placebo-controlled study

Российский кардиологический журнал, 2005
In a placebo-controlled study, propafenone efficacy and safety for pharmaceutical cardioversion in atrial fibrillation (AF) paroxysms were studied. The study included 50 patients aged 28-69 years (mean age 53,9+9,7), with AF paroxysms lasting for less ...
Yu. A. Bunin, L. K. Anfalova
doaj  

Propafenone-Induced Cholestatic Liver Injury: When Diagnosis Does Not Skip a Beat

GE: Portuguese Journal of Gastroenterology
Introduction: Propafenone is a widely used class Ic antiarrhythmic drug that is mainly metabolised by the liver. Hepatotoxicity associated with propafenone is rare, with only a few clinical cases reported in the literature.
Ana Isabel Ferreira, Vítor Macedo Silva, Cátia Arieira, Sofia Xavier, Joana Magalhães, José Cotter   +5 more
doaj   +1 more source

Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes

PLoS ONE, 2015
Flecainide blocks ryanodine receptor type 2 (RyR2) channels in the open state, suppresses arrhythmogenic Ca2+ waves and prevents catecholaminergic polymorphic ventricular tachycardia (CPVT) in mice and humans.
E. Savio-Galimberti, B. Knollmann
semanticscholar   +1 more source

Stereoselective disposition and pharmacologic activity of propafenone enantiomers. [PDF]

, 1989
H K Kroemer, Christian Funck‐Brentano, David Silberstein, A J Wood, Michel Eichelbaum, Raymond L. Woosley, Dan M. Roden   +6 more
openalex   +1 more source