Results 11 to 20 of about 7,913 (179)

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [PDF]

Journal for ImmunoTherapy of Cancer
Background Despite the successful application of immunotherapy, both innate and acquired resistance are typical in melanoma. Ferroptosis induction appears to be a potential strategy to enhance the effectiveness of immunotherapy. However, the relationship
Hong Liu, Qian Zhou, Yi He, Xiang Chen, Hui Su, Yu Meng, Yating Dian, Lei Yao, Yuming Sun, Daishi Li, Yixiao Xiong, Furong Zeng, Xiaowei Liang, Guangtong Deng   +13 more
doaj   +3 more sources

Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population

Clinical and Translational Science, 2022
Propafenone is an antiarrhythmic drug metabolized primarily by cytochrome P450 2D6 (CYP2D6). In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking.
Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, Sara L. Van Driest   +5 more
doaj   +2 more sources

The Efficacy Comparison Between Guan-Fu Base A Hydrochloric Injection vs. Propafenone Hydrochloric Injection in the Treatment of Arrhythmia: Systemic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine, 2021
Objective: To determine using a systematic assessment and meta-analysis if GFA injection is an appropriate substitute of propafenone for arrhythmic.Design: Conduct a systematic review and meta-analysis of randomized controlled trials.Data Source: PubMed,
Jinming Song, Yao Tang, Chao Gao, Xiaofeng Hou, Xinyue Liu, Zongpei Xu   +5 more
doaj   +2 more sources

Chronic Propafenone Application Increases Functional K_IR2.1 Expression In Vitro

Pharmaceuticals, 2023
Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but ...
Encan Li, Willy Kool, Liset Woolschot, Marcel A. G. van der Heyden   +3 more
doaj   +2 more sources

Propafenone-Induced QRS Widening in a Child With Arrhythmogenic Right Ventricular Cardiomyopathy: A Case Report and Literatures Review

Frontiers in Pediatrics, 2020
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare cardiac disease in children, and can lead to sudden cardiac death (SCD). Propafenone is classIC antiarrhythmic medication, and its side effects include cardiovascular compromise in the form
Yan-qiu Chu, Ce Wang, Xue-mei Li, Hong Wang   +3 more
doaj   +2 more sources

The Effect of CYP2D6 Phenotypes on the Pharmacokinetics of Propafenone: A Systematic Review and Meta-Analysis

Pharmaceutics, 2022
Propafenone (PPF) is a class 1C antiarrhythmic agent mainly metabolized by cytochrome (CYP) 2D6, CYP1A2, and CYP3A4. Previous studies have shown that CYP2D6 polymorphism influences the pharmacokinetics (PK) of PPF.
Quyen Thi Tran, In-hwan Baek, Na-young Han, Hwi-yeol Yun, Jung-woo Chae   +4 more
doaj   +2 more sources

Propafenone and propranolol dual toxicity

Journal of the American College of Emergency Physicians Open, 2020
Propranolol is a highly lipid‐soluble beta‐receptor antagonist and propafenone is a potent class 1c anti‐arrhythmic agent with strong Na‐channel blockade effect.
Moonis Farooq, Faisal Qureshi, Wael Kamkoum, Feras Abuzeyad   +3 more
doaj   +2 more sources

A case of propafenone toxicity in the setting of dehydration and acute kidney injury. [PDF]

Glob Cardiol Sci Pract
Propafenone is a class 1C antiarrhythmic and is one of the first-line drugs used in the management of atrial fibrillation. Its toxicity is rare, yet potentially life-threatening.
Haddad E, Collins M.
europepmc   +2 more sources

“Pill-in-the-Pocket” Treatment of Propafenone Unmasks ECG Brugada Pattern in an Atrial Fibrillation Patient With a Common SCN5A R1193Q Polymorphism

Frontiers in Physiology, 2019
Background: “Pill-in-the-pocket” (PIP) treatment with type IC drugs for cardioversion of recent-onset atrial fibrillation (AF) has been recommended in guidelines.
Linling Li, Yanfei Ruan, Nian Liu, Qianqian Zhao, Mengxia Zhang, Xin Li, Song Zuo, Jiang Le, Kui Wu, Rong Bai, Changsheng Ma   +10 more
doaj   +2 more sources

Efficacy and safety of 1C class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock compared to amiodarone: protocol of a prospective randomised double-blind study

BMJ Open, 2019
Introduction Supraventricular arrhythmias contribute to haemodynamic compromise in septic shock. A retrospective study generated the hypothesis that propafenone could be more effective than amiodarone in achieving and maintaining sinus rhythm (SR ...
Martin Balik, Petr Waldauf, Michal Maly, Vojtech Matousek, Tomas Brozek, Jan Rulisek, Michal Porizka, Robert Sachl, Michal Otahal, Petr Brestovansky, Eva Svobodova, Marek Flaksa, Zdenek Stach, Jaroslav Pazout, Frantisek Duska, Ondrej Smid, Martin Stritesky   +16 more
doaj   +2 more sources