“Pill-in-the-Pocket” Treatment of Propafenone Unmasks ECG Brugada Pattern in an Atrial Fibrillation Patient With a Common SCN5A R1193Q Polymorphism [PDF]
Frontiers in Physiology, 2019 Background: “Pill-in-the-pocket” (PIP) treatment with type IC drugs for cardioversion of recent-onset atrial fibrillation (AF) has been recommended in guidelines.
Linling Li +10 more
doaj +2 more sources
Cardiology Journal, 2023 BACKGROUND: Flecainide and propafenone are Class Ic antiarrhythmic drugs that block the cardiac fast inwards Na+ current and are used for rhythm control in patients with atrial fibrillation (AF). However, data on long-term clinical efficacy and safety of
Boldizsar Kovacs +4 more
doaj +3 more sources
Propafenone and amiodarone efficacy in paroxysmal atrial fibrillation treatment
Российский кардиологический журнал, 2006 To assess antiarrhythmic efficacy of propafenone and amiodarone in paroxysmal atrial fibrillation (AF) treatment, 204 patients (125 males, 79 females, aged 57-72 years) with various stages of heart failure (HF) were examined.
N. N. Isakova +5 more
doaj +3 more sources
Beyond the Michaelis-Menten: Evaluation of a tQSSA-Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Vu NT +6 more
europepmc +2 more sources
КардиоСоматика, 2015 Currently pulmonary veins isolation becomes one of the approaches for invasive treatment of paroxysmal atrial fibrillation (AF). One of difficult and unexplored problems associated with this procedure is management of patients in postoperative period ...
A. V Tarasov +2 more
doaj +2 more sources
Long-Term Outcomes of Catheter Ablation in Ventricular Tachycardia Electrical Storm: A Retrospective Cohort Study. [PDF]
Clin CardiolDespite high acute success, catheter ablation for electrical storm is associated with substantial recurrence and mortality. This study emphasizes the complex substrate and high‐risk profile of this population, underscoring the need for careful long‐term management.
Çöteli C +4 more
europepmc +2 more sources
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Structural Insights into Differences in Drug-binding Selectivity between Two Forms of Human α1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms [PDF]
, 2011 Human α1-acid glycoprotein (hAGP) in serum functions as a carrier of basic drugs. In most individuals, hAGP exists as a mixture of two genetic variants, the F1*S and A variants, which bind drugs with different selectivities. We prepared a mutant of the A
Curry, S +10 more
core +2 more sources
Kinetic analysis of drug release from nanoparticles [PDF]
, 2008 PURPOSE. Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release.
Adibkia, Khosro +8 more
core +2 more sources
Pharmacogenomic testing and its future in community pharmacy [PDF]
, 2020 Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core +1 more source