Results 31 to 40 of about 5,559 (204)
Acta Ophthalmologica, EarlyView.Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata +4 more
wiley +1 more source
Propafenone-mexiletine combination for the treatment of sustained ventricular tachycardia
, 1992 Objectives. The purpose of this study was to explore the efficacy of combined therapy with propafenone and mexiletine for control of sustained ventricular tachycardia.Background.
Murdock, Challon J. +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh +5 more
wiley +1 more source
Cardiology Journal, 2023 BACKGROUND: Flecainide and propafenone are Class Ic antiarrhythmic drugs that block the cardiac fast inwards Na+ current and are used for rhythm control in patients with atrial fibrillation (AF). However, data on long-term clinical efficacy and safety of
Boldizsar Kovacs +4 more
doaj +1 more source
Advances in cardiac devices and bioelectronics augmented with artificial intelligence
The Journal of Physiology, EarlyView.Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark +3 more
wiley +1 more source
Propafenone for conversion and prophylaxis of atrial fibrillation
, 1997 Pharmacologic therapy is widely used for restoration of sinus rhythm and prevention of recurrences of atrial fibrillation. Because concerns have been raised about their potential proarrhythmic effects, therapeutic regimens should be evaluated by placebo ...
Stiels, B. +3 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 3, June 2026.Reduced (absolute value) left ventricular global longitudinal strain is independently associated with an increased risk of appropriate therapies from primary prevention implantable cardioverter defibrillators. ABSTRACT Background Left ventricular ejection fraction (LVEF) has not demonstrated reliability in predicting ventricular arrhythmias or ...
Justin Rackley +7 more
wiley +1 more source
Acute Propafenone Toxicity Discovered after Unknown Onset of Symptoms
, 2013 Propafenone is a class 1C antiarrhythmic with sodium channel and beta blocking properties. At toxic doses it causes wide range of arrhythmias including cardiac conduction abnormalities, AV block and prolongation of QRS complexes that may be fatal.
Solakoğlu, Görkem Alper +4 more
core +1 more source