Results 21 to 30 of about 5,559 (204)

Clinical pharmacology of propafenone.

, 1983
We determined the efficacy, pharmacokinetics, and plasma concentration-response relationships of propafenone, a promising new antiarrhythmic drug. Thirteen patients with frequent and complex ventricular premature beats were studied after receiving four ...
D C Harrison, S J Connolly, C S Lebsack, R E Kates, R A Winkle   +4 more
core   +1 more source

Propafenone: A Novel Type Ic Antiarrhythmic Agent

, 1989
Propafenone is an investigational type Ic antiarrhythmic agent that markedly slows conduction velocity in all cardiac tissues. Propafenone also possesses weak beta- and calcium-channel blocking properties.
Patrick L. McCollam, Jerry L. Bauman, Robert B. Parker   +2 more
core   +1 more source

“Pill-in-the-Pocket” Treatment of Propafenone Unmasks ECG Brugada Pattern in an Atrial Fibrillation Patient With a Common SCN5A R1193Q Polymorphism

Frontiers in Physiology, 2019
Background: “Pill-in-the-pocket” (PIP) treatment with type IC drugs for cardioversion of recent-onset atrial fibrillation (AF) has been recommended in guidelines.
Linling Li, Yanfei Ruan, Nian Liu, Qianqian Zhao, Mengxia Zhang, Xin Li, Song Zuo, Jiang Le, Kui Wu, Rong Bai, Changsheng Ma   +10 more
doaj   +1 more source

Stereoselective disposition and pharmacologic activity of propafenone enantiomers.

, 1989
Propafenone is an antiarrhythmic drug that produces a variable degree of beta-blockade in humans and is administered as a racemate. To examine the relative contribution of the individual enantiomers to pharmacologic effects seen during treatment with ...
R L Woosley, A J Wood, D M Roden, D J Silberstein, C Funck-Brentano, H K Kroemer, M Eichelbaum   +6 more
core   +1 more source

Detoxification effects of long-chain versus a mixture of medium- and long-chain triglyceride-based fat emulsion on propafenone poisoning

Brazilian Journal of Medical and Biological Research
In the present study, we aimed to compare the detoxifying effects of two fat emulsions containing either long-chain triglyceride or a mixture of medium-chain and long-chain triglycerides in the propafenone-poisoned rat model.
Xusheng An, Yong Mei, Hao Sun, Jinsong Zhang   +3 more
doaj   +1 more source

EFFICACY AND SAFETY OF SINUS RHYTHM RESTORATION WITH AMIODARONE AND PROPAFENONE IN OUTPATIENTS, ECONOMIC ASPECTS (BASED ON DATA OF N.A. SEMASHKO NORTHERN MEDICAL CLINICAL CENTER)

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study efficacy and safey of sinus rhythm restoration with amiodarone and propafenone in outpatients with recurrent atrial fibrillation (AF), and to estimate pharmacoeconomic efficiency of such cardioversion in comparison with hospital treatment ...
T. A. Istomina, E. V. Serdechnaya, L. A. Kulminskaya, B. A. Tatarskiy, E. V. Kazakevich, V. L. Lipskiy, S. I. Martyushov   +6 more
doaj   +1 more source

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy

, 1990
We evaluated the antiarrhythmic efficacy and the minimal effective concentrations of propafenone and its metabolite 5-hydroxy-propafenone during a) acute intravenous infusion (1.5 mg/kg in bolus followed by 45 minutes infusion), b) an acute oral single ...
FRABETTI L, STROCCHI E, MAGNANI B., CAPUCCI A, BORIANI, Giuseppe, AMBROSIONI E, MARCHESINI B, BALDUCELLI M, TOMASI L   +8 more
core   +1 more source

Optimization of Propafenone Analogues as Antimalarial Leads

, 2016
Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug’s potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities ...
Martina S. Sigal (2148163), Joseph L. Derisi (2148157), R. Kiplin Guy (160393), David J. Lowes (2148166), Emily B. Wilson (123882), Andrew S. Lemoff (2148160), Michele C. Connelly (1416901), Julie A. Clark (2064913), W. Armand Guiguemde (727332), Fangyi Zhu (1416895)   +9 more
core   +1 more source

PROPAFENONE FOR SINUS RHYTHM RECOVERY AND SUPPORT IN PATIENTS WITH PERSISTENT FORM OF AURICULAR FIBLILLATION. “PROMETHEUS” – OPENED MULTICENTER STUDY IN RUSSIAN FEDERATION

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study efficiency and safety of propafenone internally used for recovery and support of sinus rhythm in patients with the persistent form of auricular fibrillation (AF). Material and methods. 503 patients with the persistent form of AF, aged 31-68
I. G. Fomina, A. I. Tarzimanova, A. V. Vetluzsky   +2 more
doaj   +2 more sources