Results 11 to 20 of about 4,419 (119)

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, Volume 183, Issue 15, Page 4145-4162, August 2026.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

The Journal of Physiology, Volume 604, Issue 13, Page 5139-5158, 1 July 2026.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark, Eric Rytkin, Andrei Alexandru Mircea, Igor R. Efimov   +3 more
wiley   +1 more source

Left Ventricular Global Longitudinal Strain Is Associated With Appropriate Therapies for Ventricular Arrhythmias Independent of Left Ventricular Ejection Fraction in Patients With Primary Prevention Defibrillators

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Reduced (absolute value) left ventricular global longitudinal strain is independently associated with an increased risk of appropriate therapies from primary prevention implantable cardioverter defibrillators. ABSTRACT Background Left ventricular ejection fraction (LVEF) has not demonstrated reliability in predicting ventricular arrhythmias or ...
Justin Rackley, Muhammad Soofi, Gregory M. Burkman, Carlos Contreras, Habib Yazgi, Mario D. Gonzalez, Gerald V. Naccarelli, Ankit Maheshwari   +7 more
wiley   +1 more source

A Comprehensive Assessment of Renal Function During and After Pulsed Field Ablation

Journal of Cardiovascular Electrophysiology, Volume 37, Issue 6, Page 1259-1267, June 2026.
ABSTRACT Background Acute kidney injury is an uncommon complication of pulsed field ablation (PFA). There is, however, limited empirical data on the dynamics of renal biomarkers apart from creatinine. Furthermore, no study to date has assessed creatinine at more than 24 h after the procedure. Methods Patients undergoing PFA for atrial fibrillation (AF)
Václav Melenovský, Marek Hozman, Sabri Hassouna, Ivana Fišerová, Barbora Bačová, Dalibor Heřman, Jakub Karch, Jana Veselá, Michal Zuzčák, Ivan Rychlík, Pavel Osmančík   +10 more
wiley   +1 more source

Long‐Term Outcomes of Radiofrequency Atrioventricular Node Ablation in a Real‐World Population

Pacing and Clinical Electrophysiology, Volume 49, Issue 6, Page 698-706, June 2026.
ABSTRACT Background While interventional strategies have expanded the options for long term rhythm restoration, rate control continues to play a pivotal role in the treatment of atrial arrhythmias; however, pharmacologic strategies alone often fail in achieving effective rate control.
Vanessa Sciacca, Nora‐Kristin Brandt, Thomas Fink, Denise Guckel, Maximilian Mörsdorf, Yuri Bocchini, Martin Braun, Moneeb Khalaph, Karen Harutyunyan, Nadica Trajkovska, Philipp Lucas, Thomas Eitz, Maxim Didenko, Philipp Sommer, Christian Sohns   +14 more
wiley   +1 more source

Efficacy and Safety of Catheter Ablation for Atrial Arrhythmias in Solid Organ Transplant Recipients: A Single‐Center Experience

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Catheter ablation for complex atrial arrhythmias in solid organ transplant recipients is feasible using contemporary techniques, with arrhythmia‐free survival and periprocedural complication rates comparable to matched non‐transplant controls. ABSTRACT Introduction Atrial arrhythmias are common among solid organ transplant recipients and independently ...
Piotr Gardziejczyk, Martyna Skrzyńska‐Kowalczyk, Marta Skowrońska, Ewa Wlazłowska‐Struzik, Pawel Szymkiewicz, Piotr Pruszczyk, Jakub Baran   +6 more
wiley   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Propafenone is associated with fewer recurrences of supraventricular arrhythmias in mechanically ventilated patients with septic shock and right ventricular dysfunction. [PDF]

Front Cardiovasc Med
Balik M, Tencer T, Svobodova E, Otahal M, Jurisinova I, Kaspar V, Krajcova A, Duska F, Waldauf P.   +8 more
europepmc   +1 more source