Results 161 to 170 of about 1,668 (193)

ChemInform Abstract: SYNTHESIS AND ADRENERGIC β‐BLOCKING ACTIVITY OF SOME PROPANOLAMINE DERIVATIVES

Chemischer Informationsdienst, 1978
AbstractEs werden einige Propanolamin‐Derivate wie z.B. (I) und (II) dargestellt, von denen erstere bessere β‐Blocker als Sotalol sind.
H. OBASE, H. TATSUNO, K. GOTO, K. SHIGENOBU, Y. KASUYA, Y. YAMADA, K. FUJII, S. YADA   +7 more
openaire   +1 more source

Synthesis of carbon‐14 labeled (±)‐2‐methyl‐3,3‐diphenyl‐3‐propanolamine (2‐MDP)

Journal of Labelled Compounds and Radiopharmaceuticals, 1988
AbstractThe preparation of 14C labeled (±)‐2‐methyl‐3,3‐diphenyl‐3‐propanolamine (3) from [14C]‐carbonyl‐benzophenone is described.
Brian De Costa, Andrew Thurkauf, Arthur E. Jacobson, Kenner C. Rice   +3 more
openaire   +1 more source

Pharmacokinetic Studies on Some Novel (2-Nitro-1-Imidazolyl) Propanolamine Radiosensitizers

1982
One area of current interest in radiosensitizer development is in the use of nitroimidazoles of a more polar nature than misonida-zole, combining the benefits of a shorter half-life, and thus reduced tissue exposure, which has been correlated with the neuropathy observed with misonidazole (1), while also minimising brain penetration through the blood ...
M. R. L. Stratford, A. I. Minchinton, F. A. Stewart, V. S. Randhawa   +3 more
openaire   +1 more source

ChemInform Abstract: β‐ADRENERGIC BLOCKING AGENTS. α‐ AND Γ‐METHYL(ARYLOXY)PROPANOLAMINES

Chemischer Informationsdienst, 1982
Abstractα‐Naphthol und Phenole (I) reagieren mit dem Epoxid (II) und Aminen zu den Aminoethern (III) und (IV), die durch Säulenchromatographie an Kieselgel voneinander getrennt werden können.
T. L. LEMKE, M. B. CRAMER, S. W. ADAMSKI, C. A. PEDONE, G. BROOKER   +4 more
openaire   +1 more source

Synthesis and beta-adrenergic antagonist activity of novel (3-oxazolinyl-1,4-dihydropyridyl) propanolamines.

Drug design and discovery, 1992
A novel class of 1-(1-[4-phenyl(n-butyl or methyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4- dihydropyridyl])-3-tert-butyl(or isopropyl)amino-2-propanols (7-12) were synthesized for evaluation as beta-adrenergic antagonists. Replacement of the naphthyloxy moiety of propranolol by a 1-[1-(4-n-butyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyrid yl] group ...
D, Vo, M W, Wolowyk, E E, Knaus
openaire   +2 more sources

2-methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA)

Pharmacology Biochemistry and Behavior, 1986
Using electrophoretic application to rat central neurones in vivo, and bath application to frog spinal cord in vitro, 2-methyl-3,3-diphenyl-3-propanolamine was found to be a selective antagonist of N-methyl-DL-aspartate, but not of quisqualate or kainate.
J C, Blake, S N, Davies, J, Church, D, Martin, D, Lodge   +4 more
openaire   +2 more sources

The molecular structure of tri-n-propanolamine borate

Inorganic and Nuclear Chemistry Letters, 1973
Zenei Taira, Kenji Osaki
openaire   +1 more source

Synthesis and beta-adrenergic activity of a series of 3-(substituted-benzylideneaminoxy)propanolamine derivatives.

Farmaco (Societa chimica italiana : 1989), 1995
In an attempt to change the beta-adrenergic properties of completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives, from antagonist to agonist, while still retaining the beta 2-selectivity, we described, in a previous paper, the synthesis of a series of such derivatives possessing a hydroxy or methoxy group linked to the aliphatic substituent
GENTILI D, LAPUCCI, ANNALINA, MACCHIA B, MACCHIA, MARCO, MARTINELLI, ADRIANO, NENCETTI, SUSANNA, ORLANDINI, ELISABETTA, FERNI G, PINZA M.   +8 more
openaire   +2 more sources

Synthesis and adrenergic ß-blocking activity of (oxypropanolamino)-substituted [(benzylideneamino)oxy]propanolamines

1995
The N-isopropyl- and N-t-butyl-substituted 1-[o-(3-amino-2-hydroxypropoxy)benzylideneaminoxy]-3-amino-2-propa nols (7a,b) and their meta (8a,b) and para (9a,b) isomers, in which a single aromatic ring is substituted both by the oxypropanolaminic chain of (aryloxy)propanolaminic beta-adrenergic antagonists (AOPAs) and the [(methyleneamino)oxy ...
BALSAMO A, LAPUCCI, ANNALINA, MACCHIA BRUNO, MACCHIA, MARCO, ORLANDINI, ELISABETTA, ROSSELLO, ARMANDO, FERNI GIOVANNI, PINZA MARIO   +7 more
openaire   +1 more source

o-Allyloxy-phenoxy-propanolamine, eine neue Gruppe adrenergischer β-Rezeptoren-Blocker

Experientia, 1967
M. Wilhelm, P. Hedwall, M. Meier
openaire   +1 more source