Results 71 to 80 of about 46,921 (255)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Propensity score adjustment of a treatment effect with missing data in psychiatric health services research

Epidemiology, Biostatistics and Public Health, 2022
Background: Missing values are a common problem for data analyses in observational studies, which are frequently applied in health services research.
Benjamin Mayer, Bernd Puschner
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Propensity score methodology for confounding control in health care utilization databases

Epidemiology, Biostatistics and Public Health, 2022
Propensity score (PS) methodology is a common approach to control for confounding in nonexperimental studies of treatment effects using health care utilization databases.
Elisabetta Patorno , Alessandra Grotta , Rino Bellocco, Sebastian Schneeweiss   +3 more
doaj  

Demystifying Smoker's Paradox: A Propensity Score–Weighted Analysis in Patients Hospitalized With Acute Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Smoker's paradox has been observed with several vascular disorders, yet there are limited data in patients with acute heart failure (HF). We examined the effects of smoking in patients with acute HF using data from a large multicenter registry.
Suhail A. Doi, Nazmul Islam, Kadhim Sulaiman, Alawi A. Alsheikh‐Ali, Rajvir Singh, Awad Al‐Qahtani, Nidal Asaad, Khalid F. AlHabib, Ibrahim Al‐Zakwani, Mohammed Al‐Jarallah, Wael AlMahmeed, Bassam Bulbanat, Nooshin Bazargani, Haitham Amin, Ahmed Al‐Motarreb, Husam AlFaleh, Prashanth Panduranga, Abdulla Shehab, Jassim Al Suwaidi, Amar M. Salam   +19 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Outlier classification performance of risk adjustment methods when profiling multiple providers

BMC Medical Research Methodology, 2018
Background When profiling multiple health care providers, adjustment for case-mix is essential to accurately classify the quality of providers. Unfortunately, misclassification of provider performance is not uncommon and can have grave implications ...
Timo B. Brakenhoff, Kit C. B. Roes, Karel G. M. Moons, Rolf H. H. Groenwold   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Post‐endoscopic retrograde cholangiopancreatography pancreatitis in single‐stage endoscopic common bile duct stone removal

JGH Open, 2020
Background and Aims Papillary treatment, such as endoscopic sphincterotomy or endoscopic papillary balloon dilation, and subsequent single‐stage endoscopic stone removal are often performed for choledocholithiasis; however, the incidence of ...
Hirokazu Saito, Takehiko Koga, Masafumi Sakaguchi, Yoshihiro Kadono, Kentaro Kamikawa, Atsushi Urata, Haruo Imamura, Shuji Tada, Tatsuyuki Kakuma, Ikuo Matsushita   +9 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source