Results 41 to 50 of about 130,821 (302)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Sampling weighting strategies in causal mediation analysis

BMC Medical Research Methodology
Background Causal mediation analysis plays a crucial role in examining causal effects and causal mechanisms. Yet, limited work has taken into consideration the use of sampling weights in causal mediation analysis.
Donna L. Coffman, Haoyu Zhou, Katherine E. Castellano, Megan S. Schuler, Daniel F. McCaffrey   +4 more
doaj   +1 more source

Propensity scores common support area.

, 2021
Distribution of propensity scores across beneficiaries and non-beneficiaries. (TIF)
Poliana Rebouças (10901591), Sanni Ali (11495443), Samila Sena (9620413), Elzo Pereira Pinto Júnior (11495440), Nívea B. da Silva (11495437), Enny S. Paixão (7419110), Dandara Ramos (9439281), Daniela Almeida (647165), Laura C. Rodrigues (7354784), Maria Yury Ichihara (7354781), Maurício L. Barreto (3873409), Rosemeire L. Fiaccone (3873406)   +11 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Family formation and post-secondary educational attainment among community college and 4-year college students: a longitudinal study

Frontiers in Education
BackgroundEarly adulthood is a turning-point for educational attainment and family formation. Our understanding of whether family formation predicts educational attainment is incomplete for two growing populations: unmarried families and community ...
Janet E. Rosenbaum
doaj   +1 more source

Androgen receptor gene methylation related to colorectal cancer risk

Endocrine Connections, 2019
According to its incidence patterns, colorectal cancer (CRC) tends to occur more frequently in males than in females, and the evidence shows that CRC is a hormone-related tumor.
Tingting Xia, Hongru Sun, Hao Huang, Haoran Bi, Rui Pu, Lei Zhang, Yuanyuan Zhang, Ying Liu, Jing Xu, Justina Ucheojor Onwuka, Yupeng Liu, Binbin Cui, Yashuang Zhao   +12 more
doaj   +1 more source

Continuous versus intermittent short-acting β2-agonists nebulization as first-line therapy in hospitalized children with severe asthma exacerbation: a propensity score matching analysis

Asthma Research and Practice, 2020
Background Short-acting β2-agonist (SABA) nebulization is commonly prescribed for children hospitalized with severe asthma exacerbation. Either intermittent or continuous delivery has been considered safe and efficient.
Prapasri Kulalert, Phichayut Phinyo, Jayanton Patumanond, Chutima Smathakanee, Wantida Chuenjit, Sira Nanthapisal   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Machine learning methods for propensity and disease risk score estimation in high-dimensional data: a plasmode simulation and real-world data cohort analysis

Frontiers in Pharmacology
IntroductionMachine learning (ML) methods are promising and scalable alternatives for propensity score (PS) estimation, but their comparative performance in disease risk score (DRS) estimation remains unexplored.MethodsWe used real-world data comparing ...
Yuchen Guo, Victoria Y. Strauss, Martí Català, Annika M. Jödicke, Sara Khalid, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra   +6 more
doaj   +1 more source