Results 81 to 90 of about 1,792,800 (248)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Acetabular component placement accuracy and short-term outcomes in total hip arthroplasty: comparison of robotic arm-assisted surgery system and an augmented reality-based portable navigation

Bone & Joint Open
Aims: Precise acetabular component positioning is critical to the success of total hip arthroplasty (THA). Mako uses CT-based robotic assistance, whereas AR-hip is an augmented reality-based portable navigation system operating without preoperative CT ...
Tatsuroh Suzuki, Norio Yamamoto, Takanori Miura, Yuto Otaira, Shuji Fujiwara, Takeshi Yamashita, Takayuki Nakajima   +6 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluating State Programmes - “Natural Experiments” and Propensity Scores [PDF]

Evaluations of programmes — for example, labour market interventions such as employment schemes and training courses — usually involve comparison of the performance of a treatment group (recipients of the programme) with a control group (non-recipients ...
Denis Conniffe, Vanessa Gash, Philip J. O'Connell   +2 more
core  

Notation of Propensity Scores in 3 treatment groups.

, 2013
Notation of Propensity Scores in 3 treatment groups.
Yongji Wang (302543), Hongwei Cai (495979), Jiugang Song (495980), Ling Wang (56577), Chanjuan Li (139028), Zhiwei Jiang (139025), Jielai Xia (139031)   +6 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Gütemaße und Kriterien bei der Anwendung von Propensity Scores

GMS Medizinische Informatik, Biometrie und Epidemiologie
Propensity scores (PS) have been established as a valid alternative to conventional regression models when evaluating non-randomized treatment studies.
Kuß, Oliver, Strobel, Alexandra
doaj   +1 more source

Distribution of propensity scores in the study population.

, 2016
Distribution of propensity scores in the study population.
Burkhardt Seifert (161347), Dagmar Keller (3373712), Moritz Wurnig (3373709), Andreas Meier (3036048), Kai Higashigaito (3373715), Thomas Frauenfelder (82126), Hatem Alkadhi (82133), Katharina Martini (2802418)   +7 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source