Results 51 to 60 of about 2,386,323 (274)

Domination for Finite Proper Scoring Rules [PDF]

, 2023
Scoring rules measure the deviation between a forecast, which assigns degrees of confidence to various events, and reality. Strictly proper scoring rules have the property that for any forecast, the mathematical expectation of the score of a forecast $p$
Pruss, Alexander
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Proper Scoring Rules and Domination

, 2021
I generalize a theorem of Predd, et al.~(2009) on domination and strictly proper scoring rules to the case of non-additive scoring rules.
openaire   +2 more sources

A new example for a proper scoring rule [PDF]

Communications in Statistics - Theory and Methods, 2020
We give a new example for a proper scoring rule motivated by the form of Anderson--Darling distance of distribution functions and Example 5 in Brehmer and Gneiting (2020).
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Proper Scoring Rule for Virtual Staining

CoRR
Generative virtual staining (VS) models for high-throughput screening (HTS) can provide an estimated posterior distribution of possible biological feature values for each input and cell. However, when evaluating a VS model, the true posterior is unavailable.
Samuel Tonks, Steve Hood, Ryan Musso, Ceridwen Hopely, Steve Titus, Minh Doan, Iain B. Styles, Alexander Krull   +7 more
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

EnScale: Temporally‐Consistent Multivariate Generative Downscaling via Proper Scoring Rules

Journal of Advances in Modeling Earth Systems
The practical use of future climate projections from global circulation models (GCMs) is often limited by their coarse spatial resolution, requiring downscaling to generate high‐resolution data. Regional climate models (RCMs) provide this refinement, but
Maybritt Schillinger, Maxim Samarin, Xinwei Shen, Reto Knutti, Nicolai Meinshausen   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

RIDES: Robust Intrusion Detection System for IP-Based Ubiquitous Sensor Networks

Sensors, 2009
TheIP-based Ubiquitous Sensor Network (IP-USN) is an effort to build the “Internet of things”. By utilizing IP for low power networks, we can benefit from existing well established tools and technologies of IP networks.
Sungwon Lee, Choong Seon Hong, Muhammad Shoaib Siddiqui, Syed Obaid Amin   +3 more
doaj   +1 more source