Results 91 to 100 of about 177,045 (348)

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Gut, 2014
Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation.
E. Chambers, A. Viardot, A. Psichas, D. Morrison, K. Murphy, S. Zac-Varghese, K. Macdougall, T. Preston, Catriona Tedford, G. Finlayson, J. Blundell, Jimmy D Bell, Elizabeth Louise Thomas, S. Mt-Isa, D. Ashby, G. Gibson, S. Kolida, W. Dhillo, S. Bloom, W. Morley, S. Clegg, G. Frost   +21 more
semanticscholar   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Efeito do tratamento com aditivos químicos e inoculantes bacterianos nas perdas e na qualidade de silagens de cana-de-açúcar Effect of chemical and bacterial additives on losses and quality of sugar cane silages

Revista Brasileira de Zootecnia, 2007
Objetivou-se avaliar a eficácia de aditivos químicos e inoculantes bacterianos na inibição da produção de etanol, na diminuição das perdas de MS e na melhoria da digestibilidade in vitro de silagens de cana-de-açúcar.
André de Faria Pedroso, Luiz Gustavo Nussio, Daniele Rebouças Santana Loures, Solidete de Fátima Paziani, Maurício Scoton Igarasi, Rodrigo Michelini Coelho, Jorge Horii, Armando de Andrade Rodrigues   +7 more
doaj   +1 more source

Association of gut microbiota with portal vein pressure in patients with liver cirrhosis undergoing living donor liver transplantation

JGH Open, 2023
Background and Aim Many recent studies have shown a relationship between various systemic diseases and the gut microbiota (GM), with the gut–liver axis receiving particular attention.
Katsuya Toshida, Shinji Itoh, Yukiko Kosai‐Fujimoto, Takuma Ishikawa, Yuki Nakayama, Yuriko Tsutsui, Norifumi Iseda, Takuma Izumi, Yuki Bekki, Shohei Yoshiya, Takeo Toshima, Makoto Nakamuta, Tomoharu Yoshizumi   +12 more
doaj   +1 more source

Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival

Frontiers in Nutrition, 2018
Propionibacterium freudenreichii is a commercially relevant bacterium with probiotic potential. This bacterium can exert protective effects particularly against colorectal cancer (CRC), via the production of short chain fatty acids (SCFA), namely acetate
Marta R. Casanova, Marta R. Casanova, João Azevedo-Silva, Ligia R. Rodrigues, Ana Preto   +4 more
doaj   +1 more source

Short-Chain Fatty Acids Promote Intracellular Bactericidal Activity in Head Kidney Macrophages From Turbot (Scophthalmus maximus L.) via Hypoxia Inducible Factor-1α

Frontiers in Immunology, 2020
Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance ...
Jinjin Zhang, Hui Zhang, Miao Liu, Yawen Lan, Huiyuan Sun, Kangsen Mai, Kangsen Mai, Min Wan, Min Wan   +8 more
doaj   +1 more source

Ensiling and Fermentation of Rice Hulls With Ruminal Fluid for Medium‐Chain Carboxylate Production

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Large quantities of rice hulls are common at milling sites in Nigeria. They are a by‐product of rice processing and can contribute to environmental degradation if not properly managed. In this study, rice hulls were pretreated by ensiling at ambient temperature and then used as substrate for medium‐chain carboxylates (MCCs) production ...
Jerome Undiandeye, Silas Kiman, Ebenezer Leke Odekanle, Peter Anyin   +3 more
wiley   +1 more source

The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome

Frontiers in Nutrition, 2019
Consumption of sufficient quantities of oat products has been shown to reduce host cholesterol and thereby modulate cardiovascular disease risk. The effects are proposed to be mediated by the gel-forming properties of oat β-glucan which modulates host ...
Susan A. Joyce, Susan A. Joyce, Alison Kamil, Lisa Fleige, Cormac G. M. Gahan, Cormac G. M. Gahan, Cormac G. M. Gahan   +6 more
doaj   +1 more source

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

bioRxiv, 2017
BackgroundGut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders.
L. Hoyles, T. Snelling, Umm-Kulthum Umlai, J. Nicholson, S. Carding, R. Glen, S. McArthur   +6 more
semanticscholar   +1 more source