Results 91 to 100 of about 129,614 (305)
Epilepsia, EarlyView.Abstract Objective High‐frequency oscillations (HFOs; 250–500 Hz) in electrocorticography (ECoG) are promising biomarkers for delineating the epileptogenic zone during epilepsy surgery. Accurate, intraoperative real‐time detection of HFOs may guide surgical resection to improve seizure outcome.
Jeroen Teurlings +9 more
wiley +1 more source
Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
BioMed Research International, 2018 Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and
R. Dinis-Oliveira
semanticscholar +1 more source
Cellular and Molecular Life SciencesPropofol is a commonly used anesthetic for sedation during surgery. This drug is reported to exhibit nonanaesthetic immunomodulatory and anti-inflammatory effects. Herein, we investigated the impact of topical propofol delivery with the aim of mitigating
Huang-Ping Yu +5 more
doaj +1 more source
Improved effect and mechanism of propofol on vascular hyporeactivity in septic rats
陆军军医大学学报Objective To observe the improved effect of propofol on vascular hyporeactivity in septic rats and its underlying mechanism. Methods A total of 96 SD rats (12 weeks old, both genders, weighing 200~220 g) were randomly divided into sham group (n=16 ...
SUN Yue, ZHANG Jie, ZHANG Bindan
doaj +1 more source
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation
Current Biology, 2018 Summary The lateral habenula has been widely studied for its contribution in generating reward-related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the sedative actions of the general anesthetic propofol.
Ç. Gelegen +13 more
semanticscholar +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro
Cell Death and Disease, 2018 Parthanatos is a new form of programmed cell death. It has been recognized to be critical in cerebral ischemia–reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos.
Hanhui Zhong +10 more
semanticscholar +1 more source
Epilepsia Open, EarlyView.Abstract Objective To assess the feasibility, technical performance, and safety of a novel endovascular electroencephalogram (eEEG) electrode, EP‐01, designed for minimally invasive seizure localization in patients with drug‐resistant epilepsy. Methods This single‐center, prospective, exploratory trial enrolled five patients with drug‐resistant ...
Kota Araki +9 more
wiley +1 more source
BMC Anesthesiology, 2017 Background The anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML). Methods We systematically examined the effect of propofol and its combination with
Zhimin Tan +3 more
doaj +1 more source