Results 81 to 90 of about 135,582 (205)

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]

, 2019
The synaptic α1β2γ2 ...
Akk, Gustav, Burbridge, Ariel B, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Steinbach, Joe Henry   +5 more
core   +1 more source

A novel multivariate STeady-state index during general ANesthesia (STAN) [PDF]

, 2017
The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the frontal EEG/EMG, or autonomic state reactions (e.
A Albertin, A Castro, A Castro, A Cividjian, A Ekman, AM Zbinden, AM Zbinden, Ana Castro, B Rehberg, Catarina S. Nunes, CF Minto, DI Sessler, E Farag, Fernando Gomes de Almeida, GA Mashour, H Storm, L Barvais, L Sörnmo, M Bahoura, M Huiku, M Jeanne, M Rantanen, MPJ Paloheimo, MT Rovere La, Pedro Amorim, PS Myles, S Karri, S Mallat, SD Greenwald, T Jiang, TG Monk, TW Bouillon, TW Schnider, WS Cleveland, Z Szabó   +34 more
core   +1 more source

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

BMC Anesthesiology, 2017
Background The anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML). Methods We systematically examined the effect of propofol and its combination with
Zhimin Tan, Aixia Peng, Jingwen Xu, Mingwen Ouyang   +3 more
doaj   +1 more source

Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs [PDF]

, 2012
Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods:
A. Pape, B. Zwissler, Barton RG, Cain SM, Eisenberg E, Fontana JL, H. Kertscho, Habler OP, Haller M, Herweling A, Holt JP, Ickx BE, Kampe S, Kemming GI, Kim J, Koskolou MD, Levy PS, M. Lossen, Madjdpour C, Marik PE, McCall M, Meier J, Meier JM, Meier JM, Meier JM, Meisner FG, Messmer KF, Muldoon SM, Naguib M, O. Habler, O. Horn, P. Stein, Pape A, Pape A, Pape A, Perez V, Pittman RN, Richardson RS, Russell WC, S. Kutschker, Schumacker PT, van der Linden P, van der Linden P, van Woerkens EC, Vernon DD, Werlhof V, Zollinger A   +46 more
core   +1 more source

Comparison of serum triglyceride levels with propofol in long chain triglyceride and propofol in medium and long chain triglyceride after short term anesthesia in pediatric patients

Saudi Journal of Anaesthesia, 2014
Background: Significant increase in serum triglyceride (ST) concentration have been described in adult population after prolonged administration of propofol formulation containing long chain triglyceride (LCT).
Ishwar Bhukal, Gokul Thimmarayan, Indu Bala, Sohan Lal Solanki, Tanvir Samra   +4 more
doaj   +1 more source

Modelling general anaesthesia as a first-order phase transition in the cortex [PDF]

, 2004
Since 1997 we have been developing a theoretical foundation for general anaesthesia. We have been able to demonstrate that the abrupt change in brain state broughton by anaesthetic drugs can be characterized as a first-order phase transition in the ...
Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L.   +2 more
core   +2 more sources

A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects

Frontiers in Molecular Neuroscience
Propofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li, Xinqing Yang, Chen Chen, Ziqing Yu, Houping Wang, Ruixue Liu, Jianrong He, Bin Shu, Guangyou Duan, Erquan Zhang, Dapeng Ju, He Huang   +11 more
doaj   +1 more source

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
core   +1 more source

Skin delivery and anti-inflammatory effects of the anesthetic propofol against psoriasiform lesions through KEAP1/Nrf2/HO-1 pathway activation

Cellular and Molecular Life Sciences
Propofol is a commonly used anesthetic for sedation during surgery. This drug is reported to exhibit nonanaesthetic immunomodulatory and anti-inflammatory effects. Herein, we investigated the impact of topical propofol delivery with the aim of mitigating
Huang-Ping Yu, Shih-Chun Yang, Cheng-Yu Lin, Ahmed Alalaiwe, Hsiao-Yuan Yang, Jia-You Fang   +5 more
doaj   +1 more source

A pilot study on heart rate variability (HRV) during an inhalation bolus technique with sevoflurane of desflurane (preliminary results) [PDF]

, 2006
C
Baele, Ann, De Baerdemaeker, Luc, Kalmar, Alain, Struys, Michel, Tchounkachu, G   +4 more
core   +1 more source