Results 11 to 20 of about 218,446 (354)

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites. [PDF]

, 2018
Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic NaV channel NaChBac have demonstrated that propofol promotes channel activation ...
Bondarenko, Vasyl, Carnevale, Vincenzo, Covarrubias, Manuel, Dailey, William P., Eckenhoff, Roderic G., Granata, Daniele, Klein, Michael L., Tang, Pei, Wang, Yali, Wells, Marta M., Woll, Kellie, Xu, Yan, Yang, Elaine   +12 more
core   +4 more sources

Propofol Infusion Syndrome in Adults: A Clinical Update

Critical Care Research and Practice, 2015
Propofol infusion syndrome is a rare but extremely dangerous complication of propofol administration. Certain risk factors for the development of propofol infusion syndrome are described, such as appropriate propofol doses and durations of administration,
Aibek E. Mirrakhimov, Prakruthi Voore, Oleksandr Halytskyy, Maliha Khan, Alaa M. Ali   +4 more
doaj   +2 more sources

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clinical trial

Basic & Clinical Pharmacology & Toxicology, 2022
Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi‐centre, non‐inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non‐inferiority margin of 8% in patients undergoing ...
Junxiang Li, Xiao Wang, Jin Liu, Xia Wang, Xiangkui Li, Yaping Wang, W. Ouyang, Jun Yu Li, S. Yao, Zhaoqiong Zhu, Qulian Guo, Yonghao Yu, Jin-hai Meng, Y. Zuo   +13 more
semanticscholar   +1 more source

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

New England Journal of Medicine, 2021
BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation.
C. Hughes, P. Mailloux, J. Devlin, J. Swan, R. Sanders, A. Anzueto, J. Jackson, Aimee Hoskins, B. Pun, O. Orun, R. Raman, Joanna L. Stollings, A. Kiehl, M. Duprey, Lan N Bui, H. O'Neal, Allison Snyder, M. Gropper, K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, N. Brummel, T. Girard, R. Dittus, G. Bernard, E. W. Ely, P. Pandharipande   +26 more
semanticscholar   +1 more source

Quality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol

Drug Design, Development and Therapy, 2022
Background Remimazolam is a new medication with sedative and hypnotic effects. It has been demonstrated non-inferior to propofol in general anesthesia with regard to efficacy and safety. However, whether general anesthesia with remimazolam is better than
Y. Mao, Jin-He Guo, Jingjing Yuan, Erxian Zhao, Jianjun Yang   +4 more
semanticscholar   +1 more source

Efficacy and safety of subanesthetic doses of esketamine combined with propofol in painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial

BMC Gastroenterology, 2022
Background Painless gastrointestinal endoscopy is widely used for the diagnosis and treatment of digestive diseases. At present, propofol is commonly used to perform painless gastrointestinal endoscopy, but the high dose of propofol often leads to a ...
Yongtong Zhan, Shuqing Liang, Zecheng Yang, Qichen Luo, Shuaizhen Li, Jiamin Li, Zhaojia Liang, Yalan Li   +7 more
semanticscholar   +1 more source

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway

Frontiers in Pharmacology, 2022
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury.
Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, JinGui Yu   +8 more
semanticscholar   +1 more source

Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro

Frontiers in Pharmacology, 2022
Introduction: Cervical cancer is common in women. The present standardized therapies including surgery, chemotherapy, and radiotherapy are still not enough for treatment.
Mengjun Zhao, Pan Liu, Chen Sun, Lihua Pei, Yuguang Huang   +4 more
semanticscholar   +1 more source

Efficacy and safety of remimazolam besylate versus propofol during hysteroscopy: single-centre randomized controlled trial

BMC Anesthesiology, 2021
Background Remimazolam besylate is a newer benzodiazepine with characteristics of quick onset of effects, short maintenance and recovery times without accumulation in tissues.
Xiaoqiang Zhang, Shuang Li, J. Liu
semanticscholar   +1 more source

Effects of propofol on the development of cancer in humans

Cell Proliferation, 2020
Cancer is one of most the significant threats to human health worldwide, and the primary method of treating solid tumours is surgery. Propofol, one of the most widely used intravenous anaesthetics in surgery, was found to be involved in many cancer ...
Yichi Xu, Shuya Pan, Wenxiao Jiang, Fang Xue, Xueqiong Zhu   +4 more
semanticscholar   +1 more source