Results 11 to 20 of about 213,484 (400)

Pharmacokinetic models for propofol—defining and illuminating the devil in the detail [PDF]

British Journal of Anaesthesia, 2009
The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting. With effect-site targeting the goal is to achieve a user-defined target effect-site
Absalom, A.R., De Smet, Tom, Mani, V., Struys, Michel   +3 more
exaly   +13 more sources

Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report [PDF]

SAGE Open Medical Case Reports
Propofol is a commonly used sedative for the induction of clinical anesthesia and sedation maintenance in intensive care unit patients. However, in a minority of patients, prolonged infusion of propofol may cause metabolic acidosis, electrocardiographic ...
Haibo Zhang, Yezu Liu, Minlong Liu, Bing Li, Haima Li   +4 more
doaj   +2 more sources

Propofol Infusion Syndrome in Adults: A Clinical Update

Critical Care Research and Practice, 2015
Propofol infusion syndrome is a rare but extremely dangerous complication of propofol administration. Certain risk factors for the development of propofol infusion syndrome are described, such as appropriate propofol doses and durations of administration,
Aibek E. Mirrakhimov, Prakruthi Voore, Oleksandr Halytskyy, Maliha Khan, Alaa M. Ali   +4 more
doaj   +2 more sources

Propofol [PDF]

Journal of Pain and Symptom Management, 2010
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. The content is also available on www.palliativedrugs.com and will feature in future editions of the Hospice and Palliative Care Formulary USA and its British and Canadian counterparts. The series editors welcome
Staffan, Lundström, Robert, Twycross, Mary, Mihalyo, Andrew, Wilcock   +3 more
openaire   +5 more sources

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Frontiers in Pharmacology, 2023
Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein ...
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Soshi Narasaki, Tomoaki Urabe, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai   +15 more
doaj   +1 more source

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

New England Journal of Medicine, 2021
BACKGROUND Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation.
C. Hughes, P. Mailloux, J. Devlin, J. Swan, R. Sanders, A. Anzueto, J. Jackson, Aimee Hoskins, B. Pun, O. Orun, R. Raman, Joanna L. Stollings, A. Kiehl, M. Duprey, Lan N Bui, H. O'Neal, Allison Snyder, M. Gropper, K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, N. Brummel, T. Girard, R. Dittus, G. Bernard, E. W. Ely, P. Pandharipande   +26 more
semanticscholar   +1 more source

Quality of Recovery After General Anesthesia with Remimazolam in Patients’ Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol

Drug Design, Development and Therapy, 2022
Background Remimazolam is a new medication with sedative and hypnotic effects. It has been demonstrated non-inferior to propofol in general anesthesia with regard to efficacy and safety. However, whether general anesthesia with remimazolam is better than
Y. Mao, Jin-He Guo, Jingjing Yuan, Erxian Zhao, Jianjun Yang   +4 more
semanticscholar   +1 more source

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway

Frontiers in Pharmacology, 2022
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury.
Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, JinGui Yu   +8 more
semanticscholar   +1 more source

Efficacy and safety of subanesthetic doses of esketamine combined with propofol in painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial

BMC Gastroenterology, 2022
Background Painless gastrointestinal endoscopy is widely used for the diagnosis and treatment of digestive diseases. At present, propofol is commonly used to perform painless gastrointestinal endoscopy, but the high dose of propofol often leads to a ...
Yongtong Zhan, Shuqing Liang, Zecheng Yang, Qichen Luo, Shuaizhen Li, Jiamin Li, Zhaojia Liang, Yalan Li   +7 more
semanticscholar   +1 more source

Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro

Frontiers in Pharmacology, 2022
Introduction: Cervical cancer is common in women. The present standardized therapies including surgery, chemotherapy, and radiotherapy are still not enough for treatment.
Mengjun Zhao, Pan Liu, Chen Sun, Lihua Pei, Yuguang Huang   +4 more
semanticscholar   +1 more source