Excitable neurons, firing threshold manifolds and canards [PDF]
, 2013 We investigate firing threshold manifolds in a mathematical model of an excitable neuron. The model analyzed investigates the phenomenon of post-inhibitory rebound spiking due to propofol anesthesia and is adapted from McCarthy et al. (SIAM J. Appl. Dyn.
Kopell, Nancy +3 more
core +1 more source
Propofol induces nuclear localization of Nrf2 under conditions of oxidative stress in cardiac H9c2 cells. [PDF]
PLoS ONE, 2018 Oxidative stress contributes to myocardial ischemia-reperfusion injury, which causes cardiomyocyte death and precipitate life-threatening heart failure. Propofol has been proposed to protect cells or tissues against oxidative stress.
Takeaki Shinjo +10 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Propofol is used for anesthetic induction in cats and procedural sedation in countries where alfaxalone is not available. Studies have reported propofol-related effects in echocardiography variables in dogs and humans.
Sabrine Marangoni +7 more
doaj +1 more source
Propofol and children--what we know and what we do not know. [PDF]
, 2011 The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis.
Rigby-Jones, AE, Sneyd, JR
core +2 more sources
Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility
Scientific Reports, 2017 Significant individual susceptibility to intravenous anesthetic propofol exists. The etiology of individual variability in the response to propofol may be influenced by genetic polymorphisms in metabolic and functional pathways.
Qi Zhong +4 more
doaj +1 more source
Propofol-Based Procedural Sedation with or without Low-Dose Ketamine in Children [PDF]
, 2016 Objective Examine comparative dosing, efficacy, and safety of propofol alone or with an initial, subdissociative dose of ketamine approach for deep sedation. Background Propofol is a sedative-hypnotic agent used increasingly in children for deep sedation.
Ahmed, Sheikh Sohail +5 more
core +1 more source
Proteomes, 2022 Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation.
Timo Längrich +6 more
doaj +1 more source
Intermittent Bolus versus Continuous Infusion of Propofol for Deep Sedation during ABR/Nuclear Medicine Studies [PDF]
, 2017 Objective A comparison of intermittent bolus (IB) versus continuous infusion of propofol for deep sedation. Material and Methods A retrospective review of patients sedated for Auditory Brainstem Response (ABR)/nuclear medicine studies between September
Ahmed, Sheikh Sohail +3 more
core +1 more source
Central depressant effects and toxicity of propofol in chicks
Toxicology Reports, 2014 Propofol is an ultra-short acting anesthetic agent. The information on the pharmacological and toxicological effects of propofol in the chicken is rather limited.
A.S. Naser, F.K. Mohammad
doaj +1 more source
Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study [PDF]
, 2016 The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy.
Cao, Chen +10 more
core +2 more sources