Safety and side effects of propofol in clinical practice - literature overview
Journal of Education, Health and Sport, 2023 Introduction and purpose Since people have been conducting surgeries to improve their health, they have always faced the problem of pain that these actions inevitably bring. Propofol as an anesetic is one of the solutions to these problems. Due to the
Maciej Lambach +9 more
doaj +1 more source
Propofol Induction Reduces the Capacity for Neural Information Integration: Implications for the Mechanism of Consciousness and General Anesthesia [PDF]
, 2008 The cognitive unbinding paradigm suggests that the synthesis of cognitive information is attenuated by general anesthesia. Here, we investigated the functional organization of brain activities in the conscious and anesthetized states, based on ...
Byung-Moon Choi +4 more
core +2 more sources
Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia [PDF]
arXiv, 2021 Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level, its effects on neural circuits and overall cortical functioning, which eventually lead to unconsciousness, are ...
arxiv
Towards Real-World Applications of Personalized Anesthesia Using Policy Constraint Q Learning for Propofol Infusion Control [PDF]
, 2023 Automated anesthesia promises to enable more precise and personalized anesthetic administration and free anesthesiologists from repetitive tasks, allowing them to focus on the most critical aspects of a patient's surgical care. Current research has typically focused on creating simulated environments from which agents can learn.
arxiv +1 more source
Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery [PDF]
, 2016 The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation.
Agustí, Mercé +8 more
core +2 more sources
Increasing Robustness of the Anesthesia Process from Difference Patient's Delay Using a State-Space Model Predictive Controller [PDF]
Procedia Engineering 15 (2011) 928-932, 2013 The process of anesthesia is nonlinear with time delay and also there are some constraints which have to be considered in calculating administrative drug dosage. We present an Extended Kalman Filter (EKF) observer to estimate drug concentration in the patient's body and use this estimation in a state-space based Model of Predictive Controller (MPC) for
arxiv +1 more source
BMC Anesthesiology, 2018 Background Propofol is an excellent hypnotic drug for use in repeated radiation procedures in young children. To date, tolerance to propofol generally does not develop in pediatric patients undergoing radiation therapy.
RyungA Kang +5 more
doaj +1 more source
On the role of the corpus callosum in interhemispheric functional connectivity in humans [PDF]
, 2017 Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal)
Hacker, Carl D. +8 more
core +2 more sources
Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME).
Cristian Durço Paço +8 more
doaj
Frontiers in Pharmacology, 2022 It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia.
Hua Yang +6 more
doaj +1 more source