Results 81 to 90 of about 213,484 (400)

SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway

Frontiers in Bioscience-Landmark, 2022
Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and anesthesia. In this study, we aimed to determine the neuroprotective mechanism of Sirtuin 3 (SIRT3) and propofol in POCD. Methods: The cognitive dysfunction
Shang Li, Yi Zhou, Huaying Hu, Xiaodong Wang, Junjun Xu, Chaobo Bai, Junliang Yuan, Dongliang Zhang   +7 more
doaj   +1 more source

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

BioMed Research International, 2018
Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and
R. Dinis-Oliveira
semanticscholar   +1 more source

The Growth of Microorganisms in Propofol and Mixtures of Propofol and Lidocaine

Survey of Anesthesiology, 1999
Propofol emulsion supports bacterial growth. Extrinsic contamination of propofol has been implicated as an etiological event in postsurgical infections. When added to propofol, local anesthetics (e.g., lidocaine) alleviate the pain associated with injecting it. Because local anesthetics have antimicrobial activity, we determined whether lidocaine would
Maria Greacen, Donald T. Jolly, Ireneusz Wachowski, Alexander S. Clanachan, John Galbraith, Jiri Hrazdil   +5 more
openaire   +4 more sources

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

Efeitos do propofol sobre o sistema de condução cardíaca Efectos del propofol sobre el sistema de conducción cardíaco Effects of propofol on the cardiac conduction system

Revista Brasileira de Anestesiologia, 2010
JUSTIFICATIVA E OBJETIVOS: Alguns estudos têm demonstrado que o uso do propofol é, algumas vezes, associado a bradiarritmias ou reversão de arritmias para ritmo sinusal.
Paulo Warpechowski, Ari Tadeu Lírio dos Santos, Paulo José Irigon Pereira, Gustavo Glotz de Lima   +3 more
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Propofol withdrawal seizures (or not) [PDF]

Seizure, 2008
Propofol is associated with abnormal motor events resembling seizures, the exact nature of these events remains to be elucidated. We describe here a case of seizure-like activity after propofol-induced conscious sedation accompanied by a prolactin rise, together suggesting that the event was ictal.
Steven R. Zeiler, Peter W. Kaplan
openaire   +3 more sources

Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw‐Rod external fixation

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that using a Pedicle screw‐Rod configuration for the external fixation of non‐articular tibial osteotomy aligns well with the principles of biological osteosynthesis, resulting in secondary bone healing characterized by callus formation and neovascularization.
Mohammad Mahdi Gooran, Ramin Mazaheri‐Khameneh, Seyed Mohammad Hashemi‐Asl, Rahim Hobbenaghi   +3 more
wiley   +1 more source

Descriptive Analysis of the Relationship Between Continuous Intravenous Insulin Infusion and Triglyceride Levels in Critically Ill Patients Receiving Propofol Infusion

Anesthesia Research
Background/Objectives: Propofol is a preferred agent for ICU sedation. Hypertriglyceridemia occurs in up to 45% of patients on propofol and has been linked with adverse effects.
Sarah R. Peppard, Jayshil J. Patel
doaj   +1 more source

Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Choriocarcinoma is a rare gestational trophoblastic tumour. Propofol is one of the commonly used intravenous anaesthetic agents and exerts an anti-tumour role in multiple cancers.
Hai Sun, Yingjian Wang, Wenyu Zhang
doaj   +1 more source