A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects
Frontiers in Molecular NeurosciencePropofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li +11 more
doaj +1 more source
Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia [PDF]
, 2001 Direct current auditory evoked potentials (DC-AEPs) are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in humans. To assess the potential usefulness of DC-AEPs as an indicator of anesthesia in humans,
Bauer, Herbert +5 more
core +1 more source
Improved effect and mechanism of propofol on vascular hyporeactivity in septic rats
陆军军医大学学报Objective To observe the improved effect of propofol on vascular hyporeactivity in septic rats and its underlying mechanism. Methods A total of 96 SD rats (12 weeks old, both genders, weighing 200~220 g) were randomly divided into sham group (n=16 ...
SUN Yue, ZHANG Jie, ZHANG Bindan
doaj +1 more source
Do Complexity Measures of Frontal EEG Distinguish Loss of Consciousness in Geriatric Patients Under Anesthesia? [PDF]
, 2018 While geriatric patients have a high likelihood of requiring anesthesia, they carry an increased risk for adverse cognitive outcomes from its use. Previous work suggests this could be mitigated by better intraoperative monitoring using indexes defined by
Caitlin M. Drover +8 more
core +2 more sources
Constrained Control of Depth of Hypnosis During Induction Phase [PDF]
arXiv, 2018 This paper proposes a constrained control scheme for the control of the depth of hypnosis during induction phase in clinical anesthesia. In contrast with existing control schemes for propofol delivery, the proposed scheme guarantees overdosing prevention while ensuring good performance.
arxiv
Input-Output Non-Linear Dynamical Systems applied to Physiological Condition Monitoring [PDF]
arXiv, 2016 We present a non-linear dynamical system for modelling the effect of drug infusions on the vital signs of patients admitted in Intensive Care Units (ICUs). More specifically we are interested in modelling the effect of a widely used anaesthetic drug (Propofol) on a patient's monitored depth of anaesthesia and haemodynamics. We compare our approach with
arxiv
BMC AnesthesiologyBackground Propofol formulated with medium- and long-chain triglycerides (MCT/LCT propofol) has rapidly replaced propofol formulated with long-chain triglycerides (LCT propofol).
Seongheon Lee +4 more
doaj +1 more source
Constructing a control-ready model of EEG signal during general anesthesia in humans [PDF]
arXiv, 2019 Significant effort toward the automation of general anesthesia has been made in the past decade. One open challenge is in the development of control-ready patient models for closed-loop anesthesia delivery. Standard depth-of-anesthesia tracking does not readily capture inter-individual differences in response to anesthetics, especially those due to age,
arxiv
Propofol differentially inhibits the release of glutamate, γ-aminobutyric acid and glycine in the spinal dorsal horn of rats [PDF]
Iranian Journal of Basic Medical Sciences, 2015 Objective(s): Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is
Jing Yang +4 more
doaj
Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]
, 2019 The synaptic α1β2γ2 ...
Akk, Gustav +5 more
core +1 more source