Results 61 to 70 of about 76,716 (294)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Criminalised Sex Work and the Violation of the Ultima Ratio Principle of Criminal Law

open access: yesTilburg Law Review
Most countries in the world impose some form of criminal sanctions on in-person sex work. Managers, clients, the sex workers themselves; the full or partial criminalisation of the in-person commercial sex market; the imposition of related sanctions such ...
Thomas Joyce
doaj   +1 more source

The Value of Behavioral Economics for EU Judicial Decision-Making

open access: yesGerman Law Journal, 2020
This Article analyzes the value of behavioral economics for EU judicial decision-making. The first part introduces the foundations of behavioral economics by focusing on cognitive illusions, prospect theory, and the underlying distinction between ...
Christoph K. Winter
doaj   +1 more source

Proportionality and precaution

open access: yesGlobal Constitutionalism
Abstract During the COVID-19 pandemic, governments worldwide invoked the ‘precautionary principle’ to justify policies designed to protect public health. This principle holds that the state may act proactively to avert harm where there is factual uncertainty about that harm and the efficacy of policies proposed to
Mark Friedman, Anthony Sangiuliano
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

EFFECTS OF A DISTANCE LEARNING COURSE FOR TEACHERS ON PROPORTIONALITY ON THEIR PERCEPTION OF SELF-EFFICACY [PDF]

open access: yesAnalele Universităţii din Craiova. Psihologie, Pedagogie
With the aim of strengthening the didactic capacity of teachers in the Frenchspeaking Belgium in the teaching of proportionality, we designed a distance training course. The training lasted four weeks and benefited a total of 93 teachers.
Laëtitia DRAGONE   +2 more
doaj   +1 more source

Turning proportionality upside down: from legitimising principle to critical tool

open access: yes, 2019
The reconstruction and analysis of the case law of the European Court of Justice of the European Union (ECJ) provides new insights into the structure and the normative implications of proportionality as a tool of judicial decision-making.
Menéndez Menéndez, Agustín José   +1 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Remarks About Targeted Killing in the Light of Public International Law

open access: yesPrzegląd Prawniczy Uniwersytetu im. Adama Mickiewicza, 2020
The premises concerning the use of force are currently changing, as are the goals and methods, which entails that appropriate adaptation and interpretation of international legal norms is required in the context of new threats and methods of combating ...
Piotr Łaski
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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