Results 91 to 100 of about 148,383 (342)

Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice

Frontiers in Behavioral Neuroscience, 2016
Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD).
Hélène Villain, Aïcha Benkahoul, A. Drougard, Marie Lafragette, E. Muzotte, Stéphane Pech, E. Bui, A. Brunet, P. Birmes, P. Roullet   +9 more
semanticscholar   +1 more source

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

The anti-cancer effect of Propranolol in K562 cell line: an in vitro study

Armaghane Danesh Bimonthly Journal, 2016
Introduction: Β-AR receptors are one of the proteins involved in cancer and stress. The therapeutic activity of β-blockers such as propranolol is attributed to the blockade of β1-adrenergic receptors (ARs).
S Bastani, M Mohamadzade, Y Pazhang
doaj  

Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma

OncoTarget, 2016
In a previous study on a xenograft model of melanoma, we showed that the beta-adrenergic receptor antagonist propranolol inhibits melanoma development by modulating angiogenesis, proliferation and cell survival.
L. Wrobel, Lloyd Bod, R. Lengagne, Masashi Kato, A. Prévost-Blondel, F. Gal   +5 more
semanticscholar   +1 more source

Catalytic Oxidation of Naphthalene and Polycyclic Arenes by Iron(III) TAML/H2O2 in Water Aiming at Their Efficient Removal from Aqua Natural Systems

Chemistry – A European Journal, EarlyView.
Fe‐TAML in the presence of hydrogen peroxide efficiently catalyzes the oxidative degradation of naphthalene in aqueous medium of neutral pH. Products are identified and key mechanistic features are discussed. Abstract The electron transfer from naphthalene at an oxidized iron TAML species (TAML = tetraamido macrocyclic ligand) is a key step of its ...
Parameswar Pal, Chimezie Anyakora, Alexander D. Ryabov, Terrence J. Collins   +3 more
wiley   +1 more source

Reasoning by analogy in the generation of domain acceptable ontology refinements [PDF]

, 2010
Refinements generated for a knowledge base often involve the learning of new knowledge to be added to or replace existing parts of a knowledge base. However, the justifiability of the refinement in the context of the domain (domain acceptability) is ...
L. Moss, L. Zhou, M. Horridge, M. Ricklefs, N. Noy, Y. Sure   +5 more
core   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Propranolol therapy for infantile hemangioma: our experience

Drug Design, Development and Therapy, 2017
Objective Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a ...
Ling Zhang, H. Wu, Wei-En Yuan, Jia-wei Zheng   +3 more
semanticscholar   +1 more source

Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies [PDF]

, 2016
Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are
Carlson, MC, Peters, J, Peters, R, Schuchman, M, Yasar, S   +4 more
core   +1 more source

Novel 4,5‐Dihydrothiazole‐Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, EarlyView.
The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła‐Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source