Results 1 to 10 of about 38,575 (293)

Proprotein Convertase Subtilisin/Kexin Type 9 and Inflammation: An Updated Review

open access: yesFrontiers in Cardiovascular Medicine, 2022
The function of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), a novel plasma protein, has mainly been involved in cholesterol metabolism in the liver, while, more interestingly, recent data have shown that PCSK9 also took part in the modulation ...
Na-qiong Wu, Jian-jun Li
exaly   +4 more sources

The proprotein convertase furin in tumour progression [PDF]

open access: yesInternational Journal of Cancer, 2017
Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Michele Bernasconi
exaly   +6 more sources

A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]

open access: yesPLoS ONE, 2014
Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Michael Wilschanski   +11 more
doaj   +5 more sources

Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types [PDF]

open access: yesViruses, 2023
The cleavage of viral surface proteins by furin is associated with some viruses’ high virulence and infectivity. The human papillomavirus (HPV) requires the proteolytic processing of its capsid proteins for activation before entry.
Gonzalo Izaguirre   +5 more
doaj   +2 more sources

Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside. [PDF]

open access: yesSignal Transduct Target Ther
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases (CVD).
Bao X   +9 more
europepmc   +2 more sources

Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock*

open access: yesCritical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: Proprotein convertase subtilisin/kexin type 9 is a central regulator of lipid metabolism and has been implicated in regulating the host response to sepsis.
Mihir R Atreya   +2 more
exaly   +2 more sources

Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors [PDF]

open access: yesTzu-Chi Medical Journal
A decrease in the levels of low-density lipoprotein receptors (LDLRs) leads to the accumulation of LDL cholesterol (LDL-C) in the bloodstream, resulting in hypercholesterolemia and atherosclerotic cardiovascular diseases.
Je-Wen Liou   +3 more
doaj   +2 more sources

Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer’s Disease

open access: yesFrontiers in Aging Neuroscience, 2019
Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first ...
Massimiliano Ruscica   +2 more
exaly   +2 more sources

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases [PDF]

open access: yesBMC Cancer, 2005
Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria   +9 more
doaj   +4 more sources

Proprotein convertases in high-density lipoprotein metabolism [PDF]

open access: yesBiomarker Research, 2013
The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members cleave amino acid residues and modulate the activity of precursor proteins.
Ron Korstanje, Seungbum Choi
core   +6 more sources

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