Proprotein Convertase Subtilisin/Kexin Type 9 and Inflammation: An Updated Review
Frontiers in Cardiovascular Medicine, 2022 The function of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), a novel plasma protein, has mainly been involved in cholesterol metabolism in the liver, while, more interestingly, recent data have shown that PCSK9 also took part in the modulation ...
Na-qiong Wu, Jian-jun Li
exaly +4 more sources
The proprotein convertase furin in tumour progression [PDF]
International Journal of Cancer, 2017 Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Michele Bernasconi
exaly +6 more sources
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]
PLoS ONE, 2014 Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Michael Wilschanski +11 more
doaj +5 more sources
Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types [PDF]
Viruses, 2023 The cleavage of viral surface proteins by furin is associated with some viruses’ high virulence and infectivity. The human papillomavirus (HPV) requires the proteolytic processing of its capsid proteins for activation before entry.
Gonzalo Izaguirre +5 more
doaj +2 more sources
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside. [PDF]
Signal Transduct Target TherProprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases (CVD).
Bao X +9 more
europepmc +2 more sources
Critical Care Medicine, 2020 Supplemental Digital Content is available in the text. Objectives: Proprotein convertase subtilisin/kexin type 9 is a central regulator of lipid metabolism and has been implicated in regulating the host response to sepsis.
Mihir R Atreya +2 more
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Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors [PDF]
Tzu-Chi Medical JournalA decrease in the levels of low-density lipoprotein receptors (LDLRs) leads to the accumulation of LDL cholesterol (LDL-C) in the bloodstream, resulting in hypercholesterolemia and atherosclerotic cardiovascular diseases.
Je-Wen Liou +3 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD) has been associated with dysregulation of brain cholesterol homeostasis. Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond the known role in the regulation of plasma low-density lipoprotein cholesterol, was first ...
Massimiliano Ruscica +2 more
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Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases [PDF]
BMC Cancer, 2005 Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria +9 more
doaj +4 more sources
Proprotein convertases in high-density lipoprotein metabolism [PDF]
Biomarker Research, 2013 The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members cleave amino acid residues and modulate the activity of precursor proteins.
Ron Korstanje, Seungbum Choi
core +6 more sources