Results 91 to 100 of about 38,575 (293)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: A genetic and proteomic multi-cohort study

PLoS ONE, 2019
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic enzyme that regulates circulating low-density lipoprotein (LDL) cholesterol levels by binding to LDL receptors (LDLR) and promoting their degradation. Although PCSK9 inhibitors
C. Picard, Alexandre Poirier, S. Bélanger, A. Labonté, D. Auld, J. Poirier   +5 more
semanticscholar   +1 more source

Proprotein convertase genes in Xenopus development [PDF]

Developmental Dynamics, 2005
AbstractProprotein convertases (PCs) are a family of serine endoproteases that proteolytically activate many precursor proteins within various secretory pathway compartments. Loss‐of‐function studies have demonstrated a critical role for these proteases in embryonic patterning and adult homeostasis, yet little is known about how substrate selectivity ...
Sylvia Nelsen, Jan L. Christian, Crispin Wong, Linnea K. Berg   +3 more
openaire   +3 more sources

Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients

JACC: Case Reports, 2020
Standard lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with ...
Bruce A. Warden, PharmD, Tina Kaufman, PhD, PA-C, Jessica Minnier, PhD, P. Barton Duell, MD, Sergio Fazio, MD, PhD, Michael D. Shapiro, DO, MCR   +5 more
doaj  

Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2012
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression.
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Emmanuelle Nicolas, Andres J.P. Klein-Szanto   +5 more
doaj   +1 more source

The E3 ubiquitin ligase c-IAP1 regulates PCSK9-mediated LDLR degradation: Linking the TNF-α pathway to cholesterol uptake [PDF]

, 2010
Proprotein convertase subtilisin/kexin type 9 (PCSK9), in addition to LDLR (low-density lipoprotein receptor) and APOB (apolipoprotein B), is one of three loci implicated in autosomal dominant hypercholesterolaemia (ADH)^1^.
Lizhi Liu, Weiming Xu
core   +1 more source

Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor

JACC: Case Reports, 2020
A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury.
June K. Pickett, MD, Maulin Shah, MD, Michael Gillette, PharmD, Peter Jones, MD, Salim Virani, MD, PhD, Christie Ballantyne, MD, Vijay Nambi, MD, PhD   +6 more
doaj  

Prenylated Flavonoids from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on the Expression of Inflammatory Mediators and Proprotein Convertase Subtilisin/Kexin Type 9.

Journal of Natural Products, 2019
Seven new prenylated flavonoids (1-7) and one new prenylated phenylpropiophenone (8) were isolated from roots and rhizomes of Sophora tonkinensis, along with nine known compounds (9-17).
Jongmin Ahn, Young-Mi Kim, H. Chae, Y. Choi, H. Ahn, Hunseung Yoo, Minseok Kang, Jinwoong Kim, Y. Chin   +8 more
semanticscholar   +1 more source

Proprotein convertase subtilisin/kexin type 9 and lipid metabolism

Current Opinion in Lipidology, 2019
Purpose of review The purpose of this review is to highlight the recent findings of one of the most promising therapeutic targets in LDL cholesterol (LDL-C) management, proprotein convertase subtilisin/kexin type 9 (PCSK9).
Stefano Spolitu, W. Dai, John A. Zadroga, L. Ozcan   +3 more
semanticscholar   +1 more source

Potential of PCSK9 as a new target for the management of LDL cholesterol

Research Reports in Clinical Cardiology, 2015
Guiliana Mombelli, Samuela Castelnuovo, Chiara PavanelloCardiovascular Department, Dyslipidemia Center, Azienda Ospedaliera Niguarda Cà Granda, Milan, ItalyAbstract: A large proportion of patients at high risk for cardiovascular disease continue ...
Mombelli G, Castelnuovo S, Pavanello C
doaj  

Functional Amyloid Formation within Mammalian Tissue [PDF]

, 2005
Amyloid is a generally insoluble, fibrous cross-β sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease.
Atanas V Koulov, Baxa, Berson, Berson, Caughey, Chakraborty, Chapman, Chen, Chen, Chiti, Christelle Alory-Jost, Cohen, Dobson, Douglas M Fowler, Eanes, Fink, Hearing, Hoashi, Jeffery W Kelly, Johnson, Jonathan Weissman, Kelly, Kenney, Kerje, Klunk, Klunk, Krebs, Land, Lashuel, Lashuel, Lee, Linke, Marks, Michael S Marks, Pawelek, Petkova, Provencher, Quevedo, Raposo, Schonthaler, Scott, Sekijima, Shorter, Si, Silvers, Singh, Spanakis, Sreerama, Tanaka, Westermark, William E Balch   +50 more
core   +4 more sources