Results 101 to 110 of about 25,303 (250)

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

Proprotein convertase inhibiting serpins along the secretory pathway

, 2007
Bentele C, Oley M, Tödtmann U, Krüger O, Ragg H. Proprotein convertase inhibiting serpins along the secretory pathway.
Bentele, C., Oley, M., Ragg, Hermann, Tödtmann, U., Krüger, O.   +4 more
core  

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

, 2016
The prototypical proprotein convertase furin proteolytically activates many precursor proteins and is essential for cellular homeostasis of the cell. Furin and other proprotein convertase are also associated with a number of diseases, including cancer ...
Arciniega, Marcelino, Huber, Robert, Steinmetzer, Torsten, Dahms, Sven O., Than, Manuel   +4 more
core   +1 more source

Additional file 1 of Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

, 2021
Additional file 1: Table S1. Correlation analysis between log-transformed PCSK9 and related-parameters in all patients (N=2293). Table S2. Multiple linear analysis of PCSK9 and coagulation-related indexes. Table S3. Cox regression analysis of PCSK9, PT-t
Jie Qian (565984), Hui-Hui Liu (162943), Cheng-Gang Zhu (303467), Qian Dong (414788), Jian-Jun Li (2004523), Na-Qiong Wu (303474), Jia Peng (508247), Ke-Fei Dou (9697307), Ming-Ming Liu (1714156), Yuan-Lin Guo (303471)   +9 more
core   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, EarlyView.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study [PDF]

, 2017
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events.
FERRI, NICOLA, S. D'Addato, D'Addato, Sergio, Silvia Marchiano, C. Borghi, Rosticci, Martina, D'Addato, Sergio, F. Fogacci, A. F. G. Cicero, Martina Rosticci, Giovannini, Marina, Brisighella Heart Study Group, Federica Fogacci, Cicero, Arrigo F. G., Margherita Botta, Paolo Magni, Marchiano, Silvia, Fogacci, Federica, M. Ruscica, Nicola Ferri, Massimiliano Ruscica, Arrigo F G Cicero, P. Magni, Borghi, Claudio, M. Giovannini, S. Marchiano, Botta, Margherita, M. Rosticci, Claudio Borghi, N. Ferri, Sergio D'Addato, Magni, Paolo, Arrigo F. G. Cicero, Marina Giovannini, Ruscica, Massimiliano, M. Botta   +35 more
core   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Polyphenols with indirect proprotein convertase inhibitory activity

International Journal of Oncology, 2013
Polyphenols, a class of natural products, have been shown to exhibit cancer protective properties. Proprotein convertases form a family of mammalian subtilisin-like serine endoproteases. Increased expression of these enzymes has been associated with numerous pathologies including cancer.
Jingjing, Zhu, Wim, Van de Ven, Alphons, Vermorken   +2 more
openaire   +3 more sources

Proprotein convertase subtilisin kexin 9 inhibitors: Current status and future directions

Journal of Clinical and Preventive Cardiology, 2017
The discovery of proprotein convertase subtilisin kexin 9 (PCSK9) has considerably changed the therapeutic options in the field of lipid management. PCSK9 reduces low-density lipoprotein receptor (LDLR) recycling, leading to a decrease of LDL cholesterol
JPS Sawhney, Saurabh Bagga
doaj   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source