Results 91 to 100 of about 17,066 (197)

The Proprotein Convertase PC7 [PDF]

Journal of Biological Chemistry, 2011
Estelle Rousselet, Suzanne Benjannet, Josée Hamelin, Maryssa Canuel, Nabil G. Seidah   +4 more
openaire   +1 more source

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations

Frontiers in Pharmacology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu, En Li, Xiaoyu Yang, Xiaoyu Yang   +3 more
doaj   +1 more source

Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins

EMBO Reports
The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein ...
Janika Schmitt, Emma Poole, Ian Groves, David J Owen, Stephen C Graham, John Sinclair, Bernard T Kelly   +6 more
doaj   +1 more source

Lipid-Lowering Efficiency and Safety of Alirocumab 300 mg Using a 2-mL Autoinjector Device in Real-World Practice: The MARS Study

Drugs - Real World Outcomes
Background Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 used for the reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk patients not reaching their LDL-C target.
Klaus G. Parhofer, Peter Bramlage, Constanze Gries, Cornelia Harder, Christiane Look, W. Dieter Paar, Ursula Rauch-Kröhnert   +6 more
doaj   +1 more source

Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

Respiratory Research
Background Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions.
Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park   +5 more
doaj   +1 more source

Clinical Evaluation Of Evolocumab For The Treatment Of Homozygous Familial Hypercholesterolemia In Chinese Patients

Therapeutics and Clinical Risk Management, 2019
Chin-Chou Huang,1–5 Min-Ji Charng2,3 1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan; 2Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 3Faculty of Medicine, School
Huang CC, Charng MJ
doaj  

PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?

Haematologica, 2015
Johann Guillemot, Nabil G. Seidah
doaj   +1 more source

Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin. [PDF]

J Med Chem
Lange RW, Boller C, Loresch M, Bloch K, Böttcher-Friebertshäuser E, Brandstetter H, Dahms SO, Steinmetzer T.   +7 more
europepmc   +1 more source

LDL receptor-independent mechanisms of proprotein convertase subtilisin/kexin type 9 in cardiovascular pathophysiology. [PDF]

Front Cardiovasc Med
Su H, Guo X, Li Q, Yuan X, Wu X, Zhao Z, Kan Y, Yang Y, Fu Z, Qi Z, Song G.   +10 more
europepmc   +1 more source

A disproportionality analysis on proprotein convertase subtilisin/kexin type 9 inhibitors and hypersensitivity and anaphylaxis. [PDF]

Sci Rep
Dermiki-Gkana F, Gravel CA, Kontogiorgis C, Douros A.   +3 more
europepmc   +1 more source