Results 81 to 90 of about 25,303 (250)

The promise of proprotein convertase subtilisin/kexin 9 inhibitors for the treatment of familial hypercholesterolemia

, 2015
Familial hypercholesterolemia comprises a constellation of genetic disorders resulting in very high cholesterol levels since childhood. If untreated, it is associated with accelerated atherosclerosis and premature cardiovascular disease.
Virani, Salim S., Ballantyne, Christie M, Pokharel, Yashashwi   +2 more
core   +1 more source

Alignment of Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor (PCSK1N) prohormone protein sequences containing the mouse KEP and Little SAAS peptides with mouse cleavage sites highlighted.

, 2020
Alignment of Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor (PCSK1N) prohormone protein sequences containing the mouse KEP and Little SAAS peptides with mouse cleavage sites highlighted.
Bruce R. Southey (19329), Jonathan V. Sweedler (19333), Sandra L. Rodriguez-Zas (19332), Justin S. Rhodes (8520096)   +3 more
core   +1 more source

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. [PDF]

, 2008
We have identified an ethylnitrosourea (ENU)-induced recessive mouse mutation (Vcc) with a pleiotropic phenotype that includes cardiac, tracheoesophageal, anorectal, anteroposterior patterning defects, exomphalos, hindlimb hypoplasia, a presacral mass ...
Arnold, SJ, Schneider, Jurgen E, Neubauer, Stefan, Johnson, Paul, Essalmani, R, Cama, Armando, Cama, A, Franklyn, Angela, El Omari, K, Ragoussis, Jiannis, Taylor, JM, Stammers, Dave, Brown, SD, Essalmani, Rachid, Arnold, Sebastian J, Capra, Valeria, Prat, Annik, Johnson, P, Bilski, Michal, Ragoussis, J, Constam, Daniel, Clarke, K, Bilski, M, Tymowska-Lalanne, Z, Schneider, JE, Mesnard, Daniel, Pieles, G, Taylor, Jennifer M, Constam, D, Jefferis, J, Jefferis, Joanna, Seidah, NG, Franklyn, A, Bentham, Jamie, Morris, Andrew, Mesnard, D, haw-Smith, Charles S, Schneider, Juergen, Bhattacharya, Shoumo, Capra, V, Stammers, D, Szumska, Dorota, Prat, A, Morris, A, El Omari, Kamel, Kaur, Kulvinder, Bhattacharya, S, Szumska, D, Shaw-Smith, C, Bentham, J, Tymowska-Lalanne, Zuzanna, Neubauer, S, Clarke, Kieran, Kaur, K, Pieles, Guido, Brown, Steve D, Shaw-Smith, Charles, Seidah, Nabil G   +57 more
core   +2 more sources

Evaluation of Serum Eotaxin and Related Biomarkers in Focal and Generalized Epilepsy

مجلة بغداد للعلوم
Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and increased mortality. Assessment of serum Eotaxin and related biomarkers offers useful information about
Fenik Ahmed Nadir, Firas Shawqi Algburi, Zeyan Abdullah Ali, Shaima Ahmed Nadir   +3 more
doaj   +1 more source

Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2012
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression.
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Emmanuelle Nicolas, Andres J.P. Klein-Szanto   +5 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Proprotein Convertase Subtilisin/kexin Type 9 Inhibitors in Clinical Practice: A Focused Update

, 2017
This article provides an updated review of the LDL-cholesterol efficacy, safety, and cardiovascular benefits of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. It focuses on evidence from numerous clinical trials and provides clinicians
null null, Evan A Stein
core   +1 more source

Cleavage activates Dispatched for Sonic Hedgehog ligand release

eLife, 2018
Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer.
Daniel P Stewart, Suresh Marada, William J Bodeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M Pruett-Miller, Stacey K Ogden   +7 more
doaj   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source