Results 81 to 90 of about 17,035 (191)

Therapeutic Strategies for Hypercholesterolemia

healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses
A high cholesterol level in the blood is associated with an increased risk of atherosclerosis and its related conditions such as heart attack and stroke.
Georg Noll, André Linka, Thomas Lüscher, Isabella Sudano   +3 more
doaj   +1 more source

Assessment of serum proprotein convertase subtilisin/kexin type 9 in pediatric sepsis syndrome

Scientific Reports
Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme released in response to the drop in cholesterol level ...
Suzan Omar Mousa, Mohamed Farouk Afifi, Noha Anwar Hassuna, Michael Fekry Yassa, Hend Mohamed Moness   +4 more
doaj   +1 more source

The effects of cholesterol-lowering drugs on neurocognitive function: systematic review and meta analysis

Frontiers in Neurology
ObjectiveTo investigate if cholesterol-lowering drugs exert effects on neurocognitive function.MethodsWe searched Pubmed, Embase and Cochrane Libarary from inception to March 23rd, 2023, and searched clinicaltrials.gov on January 23rd, 2024.
Kaiwei Li, Kaiwei Li, Ying Li, Xia Jiang, Ye Zhu, Ye Zhu   +5 more
doaj   +1 more source

The Proprotein Convertase PC7 [PDF]

Journal of Biological Chemistry, 2011
Estelle Rousselet, Suzanne Benjannet, Josée Hamelin, Maryssa Canuel, Nabil G. Seidah   +4 more
openaire   +1 more source

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations

Frontiers in Pharmacology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu, En Li, Xiaoyu Yang, Xiaoyu Yang   +3 more
doaj   +1 more source

Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins

EMBO Reports
The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein ...
Janika Schmitt, Emma Poole, Ian Groves, David J Owen, Stephen C Graham, John Sinclair, Bernard T Kelly   +6 more
doaj   +1 more source

Lipid-Lowering Efficiency and Safety of Alirocumab 300 mg Using a 2-mL Autoinjector Device in Real-World Practice: The MARS Study

Drugs - Real World Outcomes
Background Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 used for the reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk patients not reaching their LDL-C target.
Klaus G. Parhofer, Peter Bramlage, Constanze Gries, Cornelia Harder, Christiane Look, W. Dieter Paar, Ursula Rauch-Kröhnert   +6 more
doaj   +1 more source

Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

Respiratory Research
Background Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions.
Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park   +5 more
doaj   +1 more source

Clinical Evaluation Of Evolocumab For The Treatment Of Homozygous Familial Hypercholesterolemia In Chinese Patients

Therapeutics and Clinical Risk Management, 2019
Chin-Chou Huang,1–5 Min-Ji Charng2,3 1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan; 2Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 3Faculty of Medicine, School
Huang CC, Charng MJ
doaj  

PACE4 (PCSK6): another proprotein convertase link to iron homeostasis?

Haematologica, 2015
Johann Guillemot, Nabil G. Seidah
doaj   +1 more source