Results 121 to 130 of about 25,303 (250)
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Therapeutic Strategies for Hypercholesterolemia
healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins SuissesA high cholesterol level in the blood is associated with an increased risk of atherosclerosis and its related conditions such as heart attack and stroke.
Georg Noll +3 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source
Frontiers in NeurologyObjectiveTo investigate if cholesterol-lowering drugs exert effects on neurocognitive function.MethodsWe searched Pubmed, Embase and Cochrane Libarary from inception to March 23rd, 2023, and searched clinicaltrials.gov on January 23rd, 2024.
Kaiwei Li +5 more
doaj +1 more source
Advances in Immunological Combination Therapy for Colorectal Cancer
iMetaMed, Volume 2, Issue 3, September 2026.Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source
The Proprotein Convertase PC7 [PDF]
Journal of Biological Chemistry, 2011 Estelle Rousselet +4 more
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iNew Medicine, Volume 2, Issue 3, September 2026.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Frontiers in PharmacologyProprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu +3 more
doaj +1 more source
The Evolution of Medications for Obesity Management
JGH Open, Volume 10, Issue 9, September 2026.ABSTRACT This narrative review provides an overview of progress in the development of obesity medications, including a synthesis of data describing the efficacy and safety of currently available agents and emerging therapeutic options. Historically, many obesity medications have been withdrawn from the market due to safety concerns.
Jaskirath Gill, Priya Sumithran
wiley +1 more source
Medicine Bulletin, Volume 2, Issue 4, Page 388-405, September 2026.ABSTRACT Atherosclerosis remains the dominant substrate of atherosclerotic cardiovascular disease (ASCVD), yet recurrent events persist even when LDL cholesterol is driven to guideline targets, underscoring residual risk as a central limitation of contemporary prevention.
Yundong Peng +8 more
wiley +1 more source