Results 131 to 140 of about 25,303 (250)

Research Progress on Multiple Effects and Clinical Application of Proprotein Convertase Subtilisin-kexin9 Inhibitors

PCSK9 inhibitors (Proprotein convertase subtilisin-kexin9 inhibitors) not only have a good lipid-lowering effect but also have the effects of improving cardiovascular outcome, anti-inflammation, reducing oxidative stress and improving vascular ...
She, Lin-Cong, Chen, Chen, Feng, Yan, Zhang, Wei, Luo, Wen-Ping, Zhang, Ming-Ming, Wang, Jia-Xin, Sun, Yong-Xin   +7 more
core   +1 more source

Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins

EMBO Reports
The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein ...
Janika Schmitt, Emma Poole, Ian Groves, David J Owen, Stephen C Graham, John Sinclair, Bernard T Kelly   +6 more
doaj   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, Volume 34, Issue S2, Page 70-74, September 2026.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]

, 2009
Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
core  

Regulation and Function of Proprotein Convertase PC5 in Rat Aortic Vascular Smooth Muscle Cells

, 2009
PCs sind für die endoproteolytische Spaltung von zahlreichen Proproteinen, zu denen auch Integrine, EZM-Bestandteile und Peptidhormone gehören, während ihres Reifungsprozesses verantwortlich.
Kilimnik, Adam
core   +1 more source

From Guidelines to Clinical Practice: Expert Perspectives on Long‐Term Management of Obesity

Obesity, Volume 34, Issue 9, Page 1708-1717, September 2026.
ABSTRACT An international panel of experts from the U.S. and China convened to discuss the 2026 TOS–OMA–OAC Expert Guidance Statement on the Pharmacological Management of Obesity, focusing on emerging evidence, regional considerations, and challenges in translating recommendations into long‐term care.
Hong Chen, Ling Li, Junqing Zhang, Shaihong Zhu, Marc‐André Cornier, Jonathan Q Purnell   +5 more
wiley   +1 more source

Lipid-Lowering Efficiency and Safety of Alirocumab 300 mg Using a 2-mL Autoinjector Device in Real-World Practice: The MARS Study

Drugs - Real World Outcomes
Background Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 used for the reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk patients not reaching their LDL-C target.
Klaus G. Parhofer, Peter Bramlage, Constanze Gries, Cornelia Harder, Christiane Look, W. Dieter Paar, Ursula Rauch-Kröhnert   +6 more
doaj   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

166. EMBRYO IMPLANTATION IS ASSOCIATED WITH SPECIFIC EXPRESSION OF PROPROTEIN CONVERTASE 6 IN THE RABBIT UTERUS

, 2010
Proprotein convertase 5/6 (PC6) is a member of the proprotein convertase family that endoproteolytically cleave latent precursor proteins into their biologically active state.
G. Nie, S. Heng, Y. Li, J. Wang, P. K. Nicholls, Z. Sun   +5 more
core   +1 more source

Identification of a Proprotein Convertase Cleavage Site Within Peroxidasin and Its Regulation of Enzymatic Function

, 2017
Extracellular matrix is the foundation upon which all tissues are built. The basement membrane of cells in one form of extracellular matrix that’s comprised of mainly type IV collagen. Peroxidasin (Pxdn), a matrix-bound protein, is the enzyme responsible
Colon, Selene Y
core   +1 more source