Results 131 to 140 of about 38,575 (293)

Processing of Human Intestinal Prolactase to an Intermediate Form by Furin or by a Furin-like Proprotein Convertase [PDF]

, 1998
José Emilio Mesonero, Sergio M. Gloor, Giorgio Semenza   +2 more
openalex   +1 more source

Role of PCSK9 inhibitors in the management of dyslipidaemia

Indian Heart Journal
Proprotein convertase subtilisin kexin9 (PCSK9) inhibitors are novel agents that lower LDL cholesterol and reduce cardio-vascular event rate. Being expensive, these agents are reserved for those with high risk or very high risk of CV events and with ...
Tiny Nair
doaj  

Proprotein Convertase Enzyme Furin as a Biomarker for Immune-Mediated Diseases [PDF]

, 2020
Immuunivälitteiset sairaudet ovat yleistyvä ongelma väestön ikääntyessä. Tällä hetkellä käytössä olevat biomarkkerit ovat kuitenkin epätarkkoja ja ennustearvoltaan heikkoja, minkä vuoksi tämän potilasryhmän varhainen tunnistaminen ja tehokas hoito on ...
Ranta, Noora
core  

Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization [PDF]

, 2000
Jan-Willem H. P. VAN DE LOO, Meike TEUCHERT, Ilse G.L. Pauli, Evelyn Plets, Wim J.M. Van de Ven, John W.M. Creemers   +5 more
openalex   +1 more source

Lipid-Lowering Efficiency and Safety of Alirocumab 300 mg Using a 2-mL Autoinjector Device in Real-World Practice: The MARS Study

Drugs - Real World Outcomes
Background Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 used for the reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk patients not reaching their LDL-C target.
Klaus G. Parhofer, Peter Bramlage, Constanze Gries, Cornelia Harder, Christiane Look, W. Dieter Paar, Ursula Rauch-Kröhnert   +6 more
doaj   +1 more source

Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7 [PDF]

, 2000
Jean‐Claude Lissitzky, José LUIS, Jon Scott Munzer, Suzanne Benjannet, Francis PARAT, Michel Chrètien, Jacques Marvaldi, Nabil G. Seidah   +7 more
openalex   +1 more source

Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family [PDF]

, 2001
John W.M. Creemers, Diana Dominguez, Evelyn Plets, Lutgarde Serneels, Neil A. Taylor, Gerd Multhaup, Katleen Craessaerts, Wim Annaert, Bart De Strooper   +8 more
openalex   +1 more source

Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

Respiratory Research
Background Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions.
Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park   +5 more
doaj   +1 more source

Transforming hypercholesterolemia management: Spotlight on PCSK9 peptide vaccines

Cell Reports Medicine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a therapeutic target for dyslipidemia and atherosclerotic cardiovascular disease (ASCVD). Two recent studies published by Fang et al.1 and Zhang et al.2 in Cell Reports Medicine and Cell Reports ...
Amirhossein Sahebkar, Maciej Banach
doaj  

The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer

Oncogene, 2020
Zongsheng He, Lieven Thorrez, G. Siegfried, S. Meulemans, S. Evrard, S. Tejpar, A. Khatib, J. Creemers   +7 more
semanticscholar   +1 more source