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Tissue distribution and processing of proSAAS by proprotein convertases
Journal of Neurochemistry, 2001The conversion of inactive precursor proteins into bioactive neuropeptides and peptide hormones involves regulated secretory proteins such as prohormone convertases PC1 and PC2. The neuroendocrine protein 7B2 represents a specific binding protein for PC2, and the protein proSAAS, which interacts with PC1, exhibits certain structural and functional ...
M, Sayah +3 more
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The Proprotein Convertases, 20 Years Later
2011The proprotein convertases (PCs) are secretory mammalian serine proteinases related to bacterial subtilisin-like enzymes. The family of PCs comprises nine members, PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9 (Fig. 3.1). While the first seven PCs cleave after single or paired basic residues, the last two cleave at non-basic residues ...
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The proprotein convertases in health and disease
Qatar Foundation Annual Research Forum Volume 2012 Issue 1, 2012Background: The mammalian proprotein convertases (PCs) constitute a family of nine secretory serine proteases related to bacterial subtilisin and yeast kexin. Seven of them (PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7) activate cellular and pathogen precursor proteins by cleavage at single or paired basic residues, while SKI-1/S1P and PCSK9 regulate ...
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The proprotein convertases and their implication in sterol and/or lipid metabolism
Biological Chemistry, 2006The proprotein convertases represent a family of nine proteinases, comprising seven basic amino acid-specific subtilisin-like serine proteinases related to yeast kexin, known as PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7, and two other subtilases that cleave at non-basic residues, called SKI-1/S1P and NARC-1/PCSK9.
Nabil G, Seidah +2 more
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The role of proprotein convertases in cancer
2013Le cancer est à l'origine d'environ 20% des décès dans le monde occidental. En 2008, près de 12,7 millions de nouveaux cas et 7,6 millions de décès sont survenus dans le monde. Le développement du cancer est un processus multi-étapes, au cours duquel les cellules acquièrent des mutations qui mènent à une croissance cellulaire incontrôlée, l'échappement
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Mouse Models of Human Proprotein Convertase Insufficiency
Endocrine Reviews, 2021Iris Lindberg, Lindberg Iris
exaly
Natural Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Review
Combinatorial Chemistry and High Throughput Screening, 2023exaly
Proprotein Convertase 1/3 Deficiency
The Indian Journal of Pediatrics, 2017Gurinder Kumar +2 more
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